Universiteit Gent

Inbiose N.v.

Sofie De Maeseneire

Joeri Beauprez

Wim Soetaert

Sophie Roelants

Inge Van Bogaert

Eric Timmermans

Karen Saerens

The present invention relates to a method to produce mutated microorganisms which resist the phenomenon of lactose killing and to the microorganisms obtainable via said method. Such engineered microorganisms can be applied for the production of specialty products, such as but not limited to specialty carbohydrates, glycolipids and galactosylated compounds.

Mutant microorganisms resistant to lactose killing

The present invention relates to yeast species which are normally capable of producing sophorolipids but which are modified in such way that they are incapable producing the latter compounds. These sophorolipid-negative strains surprisingly display equal growth characteristics and biomass formation as their wild type counterparts and are hence useful for the production of compounds such as recombinant proteins, glycolipids, polyhydroxyalkanoates and carotenoides. In addition, the present invention discloses two glucosyltransferase genes with key-functions in sophorolipid production.

[object Object]

Growing community of inventors

Destelbergen, Belgium

Sofie De Maeseneire