Tvardi Therapeutics, Inc.

Baylor College of Medicine

Sofia De Achaval

Imran Alibhai

Beverly C Langevin

Tian Zhou

David John Tweardy

Jeffrey Scott Larson

Brad Henke

Provided herein are compositions, formulations, and (e.g., oral) dosage forms comprising a compound of Formula (I). In specific instances, such compositions comprise an emulsifier, a solubilizer, a polyethylene glycol, a surfactant, and an antioxidant. In some instances, such compositions are useful for the treatment of fibrosis, cancer, and/or chronic inflammation.

Therapeutic compounds, formulations, and uses thereof

Provided herein, in certain embodiments, are compounds of Formula I. or a pharmaceutically acceptable salt or a solvate thereof, compositions comprising a compounds of Formula I, or a pharmaceutically acceptable salt or a solvate thereof, and uses thereof such as in treating certain diseases or disorders (e.g., cancer, fibrosis, chronic inflammation).

Prodrugs of STAT3 inhibitors

Compounds as STAT3 inhibitors are described. A pharmaceutical composition comprising the same, methods of making the same, and a method for treating or preventing conditions such as cancer, chronic inflammation, and fibrosis using the same, are described.

STAT3 inhibitors

Growing community of inventors

Missouri City, TX, United States of America

Sofia De Achaval