Roche Diagnostics Operations, Inc.

Ultizyme International Ltd.

Roche Diabetes Care, Inc.

Ultizymer International, Ltd.

Sode Koji

Kazushige Mori

Kazunori Ikebukuro

Katsuhiro Kojima

Compositions, devices, kits and methods are disclosed for assaying cholesterol with a cholesterol oxidase mutant that has been modified at an amino acid residue involved in the active site. The cholesterol oxidase mutant has reduced oxidase activity while substantially maintaining its dehydrogenase activity.

Cholesterol oxidase mutants, compositions, devices, kits and uses thereof

Compositions, devices, kits and methods are disclosed for assaying glucose with a glucose oxidase mutant that has been modified at an amino acid residue involved in the active site. The glucose oxidase mutant has reduced oxidase activity while substantially maintaining its dehydrogenase activity.

Glucose oxidase mutants, compositions, devices, kits and uses thereof

In one form, a fructosyl peptidyl oxidase derived from a budding yeastfor assaying a glycated protein in a sample is provided. The fructosyl peptidyl oxidase has higher activity toward fructosyl valine as well as fructosyl valyl histidine, and may be useful in assaying HbA1c with higher sensitivity and specificity. Still, other forms include unique methods, techniques, systems and devices involving a fructosyl peptidyl oxidase.

Fructosyl peptidyl oxidase

In one form, a mutant fructosyl amino acid oxidase modified at an amino acid residue involved in a proton relay system is provided. The mutant fructosyl amino acid oxidase has reduced oxidase activity while substantially maintaining its dehydrogenase activity. Other forms include an assay device and assay method for measuring glycated protein. Still, other forms include unique methods, techniques, systems and devices involving a mutant fructosyl amino acid oxidase.

Growing community of inventors

Tokyo, Japan

Sode Koji