Chugai Seiyaku Kabushiki Kaisha

So Yamaguchi

Hitoshi Sasaki

Daisuke Kameoka

Toru Yoshizawa

Megumi Numata

Hiroko Murata

Naoka Hironiwa

In one non-limiting embodiment, the present disclosure relates to lyophilized formulations containing an IL-31 antagonist (for example, an anti-IL-31RA antibody) as an active ingredient, the lyophilized formulations further containing arginine and/or a salt thereof and sucrose and/or trehalose. In another non-limiting embodiment, the present disclosure relates to solution formulations containing an IL-31 antagonist as an active ingredient, the solution formulations further containing arginine and/or a salt thereof. In other non-limiting embodiments, the present disclosure relates to methods for stabilizing an antibody (for example, an anti-IL-31RA antibody) in an antibody-containing formulation, methods for suppressing antibody aggregation (aggregate formation) in an antibody-containing formulation, and methods for reducing components with charge heterogeneity in an antibody-containing formulation, the methods being characterized in that the formulation is prepared to contain arginine and/or a salt thereof, and/or sucrose and/or trehalose.

Anti-IL-31RA antibody-containing formulations

Methods of administering anti-IL31A antibody-containing formulations

Anti-IL31RA antibody-containing formulations

Growing community of inventors

Tokyo, Japan

So Yamaguchi