Kyowa Hakko Kirin Co., Limited

Ricoh Company, Ltd.

Kyowa Hakko Kogyo Co., Ltd.

Japan as Represented by President of National Cancer Center

Kenya Shitara

Shiro Akinaga

Toshihiko Ishii

Yuka Sasaki

Junji Kanazawa

So Ohta

Rinpei Niwa

Motoo Yamasaki

Masataka Shimoohsako

Nobuo Hanai

Hiromitsu Saito

Toshiyuki Suzawa

Satoru Nagamura

Kazuyasu Nakamura

Yoshio Hattori

Tatsuya Murakami

Emi Hosaka

Masaharu Furuya

Akiko Furuya

Atsushi Ochiai

Hiroshi Ando

Hiroaki Murakami

Mikio Ishibashi

Ichiro Miki

Manabu Izumikawa

Yasuhiro Sagawa

Toshio Ota

Ryo Takenaka

Noriaki Fukube

Kinya Yamashita

Takashi Kuwabara

Norihiko Shiraishi

Yoko Kato

Mami Akiyama

Masayo Suzuki

Mayumi Mukai

Tetsuya Ohfuchi

Mariko Nakano

Noriko Sakurai

Susume Sekine

Yuka Sakai

Toshiyuki Suzuwa

Shinobu Kawamoto

A medicament having a higher therapeutic effect than that provided by administration of a recombinant antibody against human CC chemokine receptor 4 or an antibody fragment thereof or an agent alone is provided.

Medicament comprising recombinant antibody against chemokine receptor CCR4

An operator guidance system includes a detection unit, a control unit, and an operation indicator. The detection unit is disposed in an image forming apparatus to output a combination of detection signals, and includes one or more media sensors, and one or more opening sensors. The one or more media sensors are disposed along a media conveyance path to output a media detection signal. The one or more opening sensors are disposed adjacent to an openable structure to output an opening detection signal. The control unit is connected to the detection unit to determine guidance to be provided to an operator based on the combination of detection signals, and includes a memory and a controller. The operation indicator is connected to the control unit to indicate the identified operation to the operator.

Operator guidance system and image forming apparatus incorporating same

The present invention provides an antibody which specifically recognizes three-dimensional structure of an extracellular region of a polypeptide encoded by PERP (p53 apoptosis effector related to PMP-22) gene and binds to the extracellular region. The antibody of the present invention is useful for treatment of various diseases which highly expresses a polypeptide encoded by the PERP gene. Also, a polypeptide encoded by the PERP gene or a cell expressing the polypeptide can be specifically detected by an immunological method using the antibody, so that the antibody is useful for diagnosis of various diseases related to PERP.

Anti-perp antibody

An object of the present invention is to provide a monoclonal antibody which is useful as a diagnostic agent or a therapeutic agent for a disease relating to a polypeptide encoded by Claudin-4 (hereinafter referred to as 'CLDN4') gene or a polypeptide encoded by a Claudin-3 (hereinafter referred to as 'CLDN3') gene, or a method for using the same. Accordingly, the present invention provides a monoclonal antibody or an antibody fragment thereof, which specifically recognizes three-dimensional structure of an extracellular region of CLDN4 and binds to the extracellular region; a monoclonal antibody or an antibody fragment thereof, which specifically recognizes three-dimensional structure of both of extracellular regions of CLDN3 and CLDN4 and binds to the extracellular regions; a hybridoma which produces the antibody; a DNA which encodes the antibody; a vector which comprises the DNA; a transformant obtained by transforming the vector; a process for producing an antibody or an antibody fragment thereof using the hybridoma or the transformant; and a diagnostic agent or a therapeutic agent for a disease relating to a polypeptide encoded by CLDN4 gene and/or CLDN3 gene using the antibody or the antibody fragment.

Anti-claudin-4 antibody

The present invention provides branched polyalkylene glycols useful as a chemically modifying agent for physiologically active polypeptides, wherein two single-chain polyalkylene glycols are linked to a group having a cyclic structure other than a plane structure, and wherein a group having reactivity with an amino acid side chain, an N-terminal amino group or a C-terminal carboxyl group in a polypeptide or a group convertible into the group having reactivity is linked to the group having a structure other than a plane structure.

Branched polyalkylene glycols

An image forming apparatus includes an image forming mechanism, a sheet conveyance mechanism, and a sheet detector. The image forming mechanism forms an image and transfers it onto the sheet conveyed by the sheet conveyance mechanism. The sheet detector is arranged upstream from an image transfer region and configured to detect the sheet. The sheet detector includes a light source, a plurality of photoreceptors, and a controller. The plurality of photoreceptors is arranged in line in a main-scanning direction and includes a first photoreceptor group and a second photoreceptor group. The first photoreceptor group changes output voltages when overridden by the side edge of the sheet. The second photoreceptor group includes an opposite end of the plurality of photoreceptors being out of the side edge of the sheet. The controller is configured to adjust a light emission amount in accordance with characteristics of the sheet.

Sheet detector mechanism including sheet detector further including photoreceptors, and image forming apparatus including the same

An image forming apparatus includes a recording sheet type detection device to automatically detect a type of a recording sheet. A setting device sets an image forming condition by an operator. The image forming condition includes the type of the recording sheet. An image forming device forms a visible image on the recording sheet. A sheet feeding device feeds the recording sheet to the image forming device. A controller controls the image forming apparatus not to form an image on the recording sheet when the image forming condition with regard to the type of the recording sheet set by the operator does not match the type of the recording sheet detected by the recording sheet type detection device.

Image forming apparatus capable of determining type of recording sheet to prevent sheet jam

The present invention relates to a toxin conjugate in which a residue derived from a compound having an affinity for a target cell is bound to a toxin through a spacer comprising polyalkylene glycol and dipeptide.

Toxin conjugates

Growing community of inventors

Tokyo, Japan

So Ohta