Korea Institute of Science and Technology

Korea Research Institute of Chemical Technology

Korea Research Institute of Bioscience and Biotechnology

So Ha Lee

Kyung Ho Yoo

Tae Bo Sim

Chang Hyun Oh

Ibrahim Mustafa El-Deeb

Tae Young Kim

Hwan Mook Kim

Jae Ho Kim

Hwan Geun Choi

Dong Keun Han

Jung Beom Son

Sung Yun Cho

Young Jin Ham

Eun Joo Roh

Dong Cho Han

Jae Du Ha

Jung Mi Hah

Byoung Mog Kwon

Jae Chun Ryu

Su Jin Jung

Dong Sik Park

Byung Sun Park

Disclosed are a novel pyrimidine derivative compound, a pharmaceutically acceptable salt thereof, a method for preparing the compound and a pharmaceutical use of the compound as an anticancer agent or a therapeutic agent for degenerative brain diseases. Specifically, the novel pyrimidine derivative compound has excellent inhibitory activities against kinase enzymes such as ARK5/NUAK1, ACK1, FLT3, JAK1, JAK2 and JAK2 (V617F) and thus is useful for treating and preventing leukemia, ovarian cancer, breast cancer, non-small cell carcinoma, colorectal cancer, glioma, and brain protein abnormalities such as Alzheimer's disease, progressive supranuclear palsy and frontotemporal dementia, that is, degenerative diseases caused by Tau deposition.

Multi-substituted pyrimidine derivatives with excellent kinase inhibitory activities

Disclosed are novel indazole derivatives represented by the following Chemical Formula 1 or pharmaceutically acceptable salts, hydrates or solvates thereof, and pharmaceutical compositions for the prevention or treatment of proliferative diseases, containing the same as an active ingredient. Having potent inhibitory effect against protein kinase, such as b-raf, KDR, Fms, Tie2, SAPK2a and Ret, inducing diseases caused by abnormal cell proliferation, the novel indazole derivatives can be used for the prevention or treatment of diseases caused by abnormal cell proliferation.

Indazole derivatives or pharmaceutically acceptable salts thereof as protein kinase inhibitors for proliferative diseases treatment, and a pharmaceutical composition containing the same as an active ingredient

Disclosed herein are novel pyrazole compounds, pharmaceutically acceptable salts thereof, a method for preparing the same, and uses thereof as anticancer agents.

Pyrazole compounds with inhibitory activity against ROS kinase

The present invention relates to diphenyl amine derivatives having luminescent properties, and particularly to diphenyl amines substituted with various electron-donating or electron-withdrawing groups. The compounds of the present invention show blue or blue-green luminescence, and luminescence of the compounds herein can be achieved by UV or visible light, thus being useful as a fluorescent dye or fluorescent material for an organic electroluminescence device or display.

Diphenyl amine derivatives having luminescence property

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Seoul, South Korea

So Ha Lee