Genentech, Inc.

Tenaya Therapeutics, Inc.

Forma Tm, LLC

Valo Health, Inc.

Frontier Medicines Corporation

F. Hoffmann-la Roche Ag

F. Hoffmann-la Roche Sa

Snahel Patel

Guiling Zhao

Gregory Hamilton

Huifen Chen

Michael Siu

Anthony A Estrada

Craig Stivala

Joseph P Lyssikatos

Alan G Olivero

Mark Edward Zak

Terry Kellar

Xiaozhang Zheng

Kenneth W Bair

Julio Cesar Medina

Peter Scott Dragovich

Kevin X Chen

Po-Wai Yuen

Timm R Baumeister

Daniel Shore

Yamin Zhang

Ulhas Bhatt

Frederick Cohen

Paul Gibbons

Wei Li

Pingyu Ding

Po-wai Yuen

Nicholas Charles Ray

Simon Charles Goodacre

Christine Edwards

Blake Daniels

Malcolm Huestis

Wen Liu

Tien Widjaja

Alok Nerurkar

Xiongcai Liu

David Sperandio

Mohammad A Mandegar

Liting Dong

Changyou Ma

Yun-Xing Cheng

Wen K Liu

Cuong Q Ly

Matthew W Cartwright

Guibai Liang

Frederick Seidl

Xianrui Zhao

Mohammed Sajad

Martin Holan

Monika Jane Williams

Philip A Gerken

Yihong Li

John Lee

Alan Olivero

Kevin Chen

Some embodiments of the invention provide compounds having the general formula I: wherein R, R, Rand Rare as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.

Bicyclic ketone compounds and methods of use thereof

The invention provides novel compounds having the general formula I: wherein R, R, R, n, p, q, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.

Bicyclic sulfones and sulfoxides and methods of use thereof

Provided herein are compounds identified as inhibitors of HDAC6 activity having the formula: or a pharmaceutically acceptable salt thereof, that can be used to treat various diseases and disorders.

Fluoroalkyl-oxadiazoles and uses thereof

The present disclosure provides compounds and methods useful in the treatment and suppression of cancer, for example, useful for treating or suppressing cancers characterized by KRAS G12C. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

KRAS G12C inhibitors

The invention provides novel compounds having the general formula I: wherein R, X, Z, L, n, the A ring, the B ring, and the C ring are as described herein, pharmaceutical compositions including the compounds and methods of using the compounds.

Bicyclic lactams and methods of use thereof

The invention provides novel compounds having the general formula I:

Bicyclic pyridone lactams and methods of use thereof

The invention provides novel compounds having the general formula I: wherein R, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.

The invention provides novel compounds having the general formula I: or pharmaceutically acceptable salts thereof, whereinR, R, R, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.

Bicyclic compounds for use as RIP1 kinase inhibitors

The invention provides compounds having the general formula I: or pharmaceutically acceptable salts thereof, wherein

Pyridine lactam compounds and methods of use thereof

The invention provides novel compounds having the general formula I: wherein R, R, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds and methods of using the compounds.

Bicyclic amide compounds and methods of use thereof

Provided are amido spirocyclic amide and sulfonamide compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.

Amido spirocyclic amide and sulfonamide derivatives

The present invention provides for compounds of Formula I-I and embodiments and salts thereof for the treatment of diseases (e.g., neurodegenerative diseases). R, R, R, X, X, A and Cy variable in Formula I-I all have the meaning as defined herein. 

Biheteroaryl compounds and uses thereof

Growing community of inventors

Foster City, CA, United States of America

Snahel Patel