Abbott Point of Care Inc.

Smitha R K Sutrala

Katrina Petronilla Di Tullio

Glenn Brian Martin

Steven Roy Breeze

Tian-Xian Zhao

Sheila Diane Ball

Eric Hong

Anjulia Chiu-Yuk Wong

Isabelle Louisette Thibodeau

Gordon Bruce Collier

Dan Wang

Paul W Johns

Jay Kendall Taylor

Paul Willis Johns, Jr

The present invention relates to sample analysis cartridges comprising micro-environment sensors and methods for assaying coagulation in a fluid sample applied to the micro-environment sensors, and in particular, to performing coagulation assays using micro-environment sensors in a point of care sample analysis cartridge. For example, the present invention may be directed to a sample analysis cartridge including an inlet chamber configured to receive a biological sample, and a conduit fluidically connected to the inlet chamber and configured to receive the biological sample from the inlet chamber. The conduit may include a micro-environment prothrombin time (PT) sensor, and a micro-environment activated partial thromboplastin time (aPTT) sensor.

Microfabricated device with micro-environment sensors for assaying coagulation in fluid samples

The present invention relates to ellagic acid formulations for performing coagulation assays that are highly stable for long term storage and reduce assay time. Particularly, aspects of the present invention are directed to a composition and method of preparing ellagic acid in a highly soluble format for use in a coagulation assay. For example, the ellagic acid may be solubilized in one or more of sodium hydroxide, methanol, a polyether compound, particularly polyethylene glycol, polyethylene oxide, or polyoxyethylene, and a cyclodextrin guest-host complex.

Ellagic acid formulations for use in coagulation assays

The present invention relates to analytical testing devices including micro-environment sensors and methods for assaying coagulation in a fluid sample applied to the micro-environment sensors, and in particular, performing one or more types of coagulation assays using one or more micro-environment sensors in a single point of care combined test cartridge. For example, the present invention may be directed to test sensor including at least one transducer coated with a polymer layer. The polymer layer comprises a thrombin-cleavable peptide with a detectable moiety.

Sensors for assaying coagulation in fluid samples

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Kanata, Canada

Smitha R K Sutrala