Stryker Corporation

Genera Istrazivanja D.o.o.

Perform Biologies, Inc.

Flexi Oscar D.o.o.

Slobodan Vukicevic

Kuber T Sampath

Lovorka Grgurevic

Vladimir Katic

Charles M Cohen

Hermann Oppermann

Mislav Jelic

Boris Macek

An autologous bone graft substitute composition for inducing new bone formation, promoting bone growth and treating bone defects. The composition includes autologous blood; one or more analogs of an osteogenic bone morphogenetic protein selected from BMP-6, BMP-2, BMP-7, BMP-4, BMP-5, BMP-8, BMP-9, BMP-12, and BMP-13, and combinations thereof in a range of from 2 to 1000 &#x3bc;g per ml of autologous blood; and hydroxyapatite, tri-calcium phosphate, or a mixture thereof as a compression resistant matrix, the compression resistant matrix being provided in the form of particles having a particle size in a range of from above 74 to 8000 &#x3bc;m. Preferably, a ratio between the compression resistant matrix and the autologous blood coagulum is from 50 to 500 mg of the compression resistant matrix per mL of the autologous blood coagulum.

Autologous bone graft substitute composition comprising bioceramic particles of different geometry

An autologous bone graft substitute composition for inducing new bone formation, promoting bone growth and treating bone defects, a method of preparation thereof, and a method of inducing or promoting bone growth by treatment of a bone with an autologous bone graft substitute composition. The composition includes autologous blood; one or more analogs of an osteogenic bone morphogenetic protein selected from BMP-6, BMP-2, BMP-7, BMP-4, BMP-5, BMP-8, BMP-9, BMP-12, and BMP-13, and combinations thereof; and a compression resistant matrix selected from the group consisting of a bone autograft, bone allograft, hydroxyapatite, tri-calcium phosphate, and combinations thereof. The autologous blood forms a coagulum gel comprising a fibrin-meshwork reinforced with the compression resistant matrix and containing the osteogenic bone morphogenetic protein which is released over a sustained period.

Autologous bone graft substitute composition

An external load bearing distracting device, which can be positioned to fully unload a knee joint cartilage while providing the knee joint normal motion, for an articulating anatomical joint. The device includes first and second rotatable extensions arranged longitudinally on opposite sides of the joint, and first and second translational inserts slidably arranged inside the first and second rotatable extensions, respectively. The joint may comprise a ball-and-ring-joint or a cardan joint. The first and second translational inserts include a threaded portion and a pair of threaded nuts thereon, which abut a retainer on each of the first and second rotatable extensions to limit longitudinal translation. The external load-bearing distracting device is temporarily attached to the patient, preferably for a period of 6 to 8 weeks, and is intended for use to treat osteoarthritis, focal cartilage defects, and fractures inside the knee joint, among other conditions of articulating anatomical joints.

External load bearing distracting device for an articulating anatomical joint

The present invention relates to an Autologous Bone Graft Substitute composition (ABGS) for inducing new bone formation, promoting bone growth and treating of bone defect, a preparation method of the Autologous Bone Graft Substitute composition, and a kit for preparing the Autologous Bone Graft Substitute composition of implant. In a particular aspect, the invention relates to an injectable/extrudable/implantable Autologous Bone Graft Substitute composition for use in treatment of bone defects, inducing new bone formation and promoting bone growth for bone fracture healing, spinal fusions and to repair bone defects in bone reconstructive procedures of orthopedic and oral maxillofacial-dental surgeries.

Autologous bone graft substitute

Methods and compositions are described to regenerate cartilage in a partial thickness defect or area of reduced volume of articular cartilage comprising an infiltration suppressor agent and a columnar growth promoting agent.

Methods and compositions for regenerating articular cartilage

Uses of BMP-1 isoforms for diagnosing and treating defects and disorders of bone and soft tissues are described. Also described is a newly isolated variant of the BMP-1 isoform BMP-1-3.

Methods of preventing ischemia/reperfusion damage to kidney using antibodies that bind BMP-1 isoforms

The present invention provides methods for the treatment, and pharmaceuticals for use in the treatment, of mammalian subjects in, or at risk of, acute renal failure, or subject to, or at risk of, inflammation, neutrophil-mediated cell damage, and apoptosis resulting from tissue damage or injury. The methods involve the administration of certain proteins of the osteogenic protein/bone morphogenetic protein (OP/BMP) family within the TGF-&#x3b2; superfamily of proteins.

Therapies for acute renal failure

Provided herein are methods and devices for inducing the formation of functional replacement nonarticular cartilage tissues and ligament tissues. These methods and devices involve the use of osteogenic proteins, and are useful in repairing defects in the larynx, trachea, interarticular menisci intervertebral discs, ear, nose, ribs and other fibrocartilaginous tissues in a mammal.

Method and device for repairing the larynx, trachea and other fibrocartilaginous tissues

The present invention provides methods for the treatment, and pharmaceuticals for use in the treatment, of mammalian subjects in, or at risk of chronic renal failure, or at risk of a need for renal replacement therapy. The methods involve the administration of certain proteins of, or based upon, the osteogenic protein/bone morphogenetic protein (OP/BMP) family within the TGF-&#x3b2; superfamily of proteins.

Therapies for chronic renal failure

Provided herein are methods and devices for inducing the formation of functional replacement nonarticular cartilage tissues and ligament tissues. These methods and devices involve the use of osteogenic proteins, and are useful in repairing defects in the larynx, trachea, interarticular menisci, intervertebral discs, ear, nose, ribs and other fibrocartilaginous tissues in a mammal.

Repair of ligament using osteogenic proteins

ADAMTS4 is found to be useful as a blood biomarker for chronic renal failure and also as a therapeutic target for treating chronic renal failure in a human individual. A change in the level of expression of selected genes as disclosed herein in kidney tissue of an individual may also be used to diagnose chronic renal failure in an individual.

ADAMTS4 as a blood biomarker and therapeutic target for chronic renal failure

Whole blood-derived coagulum devices are described for use in treating bone defects.

Whole blood-derived coagulum device for treating bone defects

Blood biomarkers are described for use in methods and compositions to determine whether an individual has sustained a bone fracture or a cartilage injury.

Growing community of inventors

Zagreb, Croatia

Slobodan Vukicevic