The University of Texas System

Timothy Madden

Alexander Levitzki

Moshe Talpaz

Nicholas Donato

Izabela Fokt

Slawomir Szymanski

Waldemar Priebe

Jeffrey Myers

Charles Conrad

Nicholas J Donato

Charles A Conrad

Jeffrey N Myers

Waldeman Priebe

Leposava Antonovic

Provided herein are methods of treating brain tumors by administering a therapeutically effective amount of a compound of the Formulas I or II to a patient in need thereof.

Inhibitors of glycolysis useful in the treatment of brain tumors

The present invention concerns compounds and their use to treat cell proliferative diseases such as cancer. Compounds of the present invention display significant potency as kinase inhibitors, cause the downregulation of c-myc, and inhibit the growth and survival of cancerous cell lines.

Compounds for treatment of cell proliferative diseases

The present invention concerns compounds and their use to treat cell proliferative diseases such as cancer. Compounds of the present invention display significant potency as inhibitors of Jak2/STAT3 pathways and downstream targets and inhibit the growth and survival of cancerous cell lines.

Orally bioavailable caffeic acid related anticancer drugs

Methods of treating glioblastoma and pancreatic cancer are provided by the administration of a therapeutically effective amount of a iodo-hexose compound to a subject in need thereof. The subject disclosure includes methods of treating glioblastoma and pancreatic cancer comprising the administration of a therapeutically effective amount of a 2-deoxy-2-iodo-D-hexose compound including 2-deoxy-2-iodo-D-mannose, 2-deoxy-2-iodo-D-glucose, 2-deoxy-2-iodo-D-galactose, and/or 2-deoxy-2-iodo-D-talose to a subject in need thereof.

Iodo-hexose compounds useful to treat cancer

Growing community of inventors

Houston, TX, United States of America

Slawomir Szymanski