University of Minnesota

Cargill Inc.

Torrey Pines Institute for Molecular Studies

Skye Doering

Richard Allen Houghten

Dan S Gaspard

Clemencia Pinilla

Adam T Zarth

Carrie Haskell-Luevano

Radleigh G Santos

Kristopher T Mortenson

Jon Richard Appel

Marc A Giulianotti

Marcello A Giulianotti

A method for making a caffeoylquinic composition from a botanical source is disclosed. The method may include chromatographing an extract of biomass on an ion exchange stationary phase and obtaining an eluent comprising a caffeoylquinic composition. The biomass may be stevia or yerba mate, for example. The caffeoylquinic composition includes one or more of monocaffeoylquinic acid, dicaffeoylquinic acid, and salts of the foregoing.

Methods for making botanical extract composition

The invention provides compounds having the general formula I: and salts thereof, wherein the variables R, R, Rand Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

Selective small molecule peptidomimetic melanocortin ligands

A method for making a caffeoylquinic composition from a botanical source is disclosed. The method may include chromatographing an extract of biomass on an ion exchange stationary phase and obtaining an eluent comprising a caffeoylquinic composition. The biomass may beor yerba mate, for example. The caffeoylquinic composition includes one or more of monocaffeoylquinic acid, dicaffeoylquinic acid, and salts of the foregoing.

Certain embodiments of the invention provide a compound of formula (I):R&#x2014;C(&#x2550;O)&#x2014;W&#x2014;X&#x2014;Y&#x2014;Z&#x2014;N(R)&#x2003;&#x2003;(I)or a salt thereof, wherein R, R, W, X, Y and Z are as defined herein, as well as methods of use thereof.

Melanocortin ligands and methods of use thereof

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Minneapolis, MN, United States of America

Skye Doering