Academisch Ziekenhuis Leiden (h.o.d.n. Lumc)

Other

Academish Ziekenhuis Leiden H.o.d.n. Lumc

Academisch Ziekenhuis Leiden

Sjoerd Henricus Van Der Burg

Gemma G Kenter

Cornelis Johannes Maria Melief

Rienk Offringa

Maria Johanna Philomena Schoenmaekers-Welters

Annemieke M De Jong

Annemieke Geluk

Cornelis Johannes Melief

Rene Everardus Maria Toes

Tom Henricus Maria Ottenhof

The present invention relates to novel CD4+ and CD8+ T cell epitopes that are specific for HPV-specific E6 and E7 oncoproteins, to peptides comprising these novel T cell epitopes, and to (vaccine) compositions comprising these peptides for use in methods for the prevention and/or treatment of HPV related diseases. Preferred epitopes are recognized by a T cell that infiltrates a cervical neoplastic lesion or by a T cell from a draining lymph node, and are presented by an HLA-DQ or HLA-DP molecule, or an HLA-B.

HPV epitopes targeted by T cells infiltrating cervical malignancies for use in vaccines

The invention relates to the use of a peptide derived from HPV-E2, E6 and/or E7 protein for the manufacture of a medicament for the treatment or prevention of an HPV related disease, wherein the medicament is for intradermal administration.

Intradermal HPV peptide vaccination

The invention relates to a peptide derived from p53 that could be used as a vaccine against cancer.

P53 peptide vaccine

Growing community of inventors

Leiden, Netherlands

Sjoerd Henricus Van Der Burg