Peking University

Qingdao Rising Biotechnology Co., Ltd

Siwang Yu

Song Song

Zhongjun Li

Shan Liu

Xiangbao Meng

Simin Yang

Linling Que

Ning Jiao

Yameng Liu

A phenoxy carboxylic acid compound, its pharmaceutically acceptable salt or ester, stereoisomer, prodrug, hydrate, solvate or crystal form, or metabolite form thereof, or any combination or mixture thereof; a pharmaceutical composition comprising the compound, its pharmaceutically acceptable salt or ester, stereoisomer, prodrug, hydrate, solvate or crystal form, or metabolite form thereof, or any combination or mixture thereof; and a medicinal use of the compound, its pharmaceutically acceptable salt or ester, stereoisomer, prodrug, hydrate, solvate or crystal form, or metabolite form thereof, or any combination or mixture thereof, for preventing and/or treatment of a metabolic disease (e.g., metabolic syndrome, non-alcoholic fatty liver disease, and/or diabetes mellitus).

Phenoxy carboxylic acid compounds and medical uses thereof

Provided is a fused acridine derivative as formula (I), which has good antitumor activity. In addition, also provided are a process for preparing the derivative, a pharmaceutical composition containing the derivative, and the use thereof. 

Fused acridine derivative and pharmaceutical composition, preparation method and use thereof

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Beijing, China

Siwang Yu