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Mylan Laboratories Limited

Mylan Labs Limited

Siva Rama Prasad Vellanki

Arabinda Sahu

Debashish Datta

Lakshmana Rao Vadali

Srikanth Sarat Chandra Gorantla

Shankar Rama

Srinivasa Rao Dasari

Raja Babu Balusu

Nagaraju Mittapelly

Mastan Rao Ravi

Venkata Suryanarayana Ponnekanti

Satishbabu Kothari

Vikram Vanama

Aravind Kumar Katukuri

Hari Babu Nandipati

Ravindrababu Kilaru

Naveen Kumar Phadhuri

Rama Krishna Pilli

Pravan Kumar Jujjavarapu

The present invention relates to a non-solvated crystalline Darunavir, process for its preparation and pharmaceutical composition comprising it. The present invention also relates to a process for the preparation of amorphous Darunavir from a non-solvated crystalline Darunavir.

Crystalline Darunavir

The present invention relates to an improved process for the preparation of Tenofovir Disoproxil and its pharmaceutically acceptable salts comprising the steps of: a) esterifying Tenofovir with chloromethyl isopropyl carbonate in presence of a base, phase transfer catalyst and optionally dehydrating agent, in a suitable solvent; b) optionally purifying Tenofovir Disoproxil; and c) converting of Tenofovir Disoproxil into its pharmaceutically acceptable salts. The present invention further relates to a process for the preparation of Tenofovir by reacting 1-(6-amino-purin-9-yl)-propan-2-ol with toluene-4-sulfonic acid diethoxy phosphoryl methyl ester in presence of a base in a non-polar solvent medium followed by hydrolysis.

Process for the preparation of tenofovir disoproxil fumarate

A process for the preparation of Darunavir comprises the reacting of 4-amino-N-(2R, 3S) (3-amino-2-hydroxy-4-phenylbutyl)-N-isobutyl-benzenesulfonamide with (3R, 3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol derivative in N-methyl-2-pyrrolidinone and isolating the resulting Darunavir. The process yields Darunavir with a very low level of the difuranyl impurity.

Process for the preparation of darunavir

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Hyderabad Telangana, India

Siva Rama Prasad Vellanki