Hong Kong Baptist University

Other

Siu Wai Tsang

Hongjie Zhang

Zhaoxiang Bian

Aiping Lu

Albert Sun-Chi Chan

Yegao Chen

Lei Guo

Dajian Yang

Hongxi Xu

Shilin Chen

Kanglun Liu

Tongxin Zhang

Man Shing Ricky Wong

Yu Zhu

Albert Sun Chi Chan

Che Yuen Justin Wu

Haitao Xiao

Hongyan Qin

Siu Po Ip

The present invention relates to a group of derivatives synthesized based on the ent-kaurane diterpenoid flexicaulin A and the methods to synthesize such diterpenoid derivatives. In particular, the chemical entities of such synthetic diterpene compounds in the manufacture of a medicament is for the treatment of tumors or cancers.

Method of use of diterpenoid derivatives as anticancer agents

The present invention relates to a composition for preventing or reducing microbial growth, particularly the growth of dermatophytic fungi, and/or aciduric and acidogenic gram-positive bacteria. More particularly, it relates to the use of trans-3,5,4'-trihydroxybibenzyl, also known as dihydro-resveratrol, or its dihydrostilbene derivatives and/or chemical variants as an anti-microbial agent. The present invention further relates to the management of dermatophytosis often caused by dermatophytic fungi and the management of dental caries often mediated by aciduric and acidogenic gram-positive. The present invention therefore has applications in preventing, alleviating and/or treating dermatophytosis and dental caries.

Method of using of dihydro-resveratrol or its stilbenoid derivatives and/or chemical variants as antimicrobial agents

The present invention relates to a skin-protection composition that comprises stilbenoid(s) and/or stilbenoid-containing extract(s) obtained fromplants, such asandfor the management of melanogenesis, skin-darkening and skin-aging. More particularly, it relates to the usage ofingredients and stilbenoids to reduce the formation of melanin in melanocytes. It also relates to the usage ofingredients and stilbenoids to reduce the generation of reactive oxygen species and oxidative free radicals. This invention relates to the use-derived extracts or ingredients or stilbenoids in the formulation of skin-protection, skin-whitening and/or anti-skin aging products.

[object Object]

The present invention relates to a polyphenol derivative of the stilbenoid family, namely trans-3,5,4'-trihydroxybibenzyl, also known as dihydro-resveratrol, as a remedial agent. In particular, the present invention presents the usage of dihydro-resveratrol or its derivatives/chemical variants in the manufacture of a medicament for the treatment of tumors or cancers. The dihydrostilbenes can be used in the treatment or delay of progression of a cancer in a patient or used in a pharmaceutical formulation for the aforementioned purposes.

Method of using dihydro-resveratrol or its stilbenoid derivatives and/or chemical variants in treatment of tumorous pathologies

A skin-protection composition is shown that comprises stilbenoid(s) and/or stilbenoid-containing extract(s) obtained fromplants, such asandfor the management of melanogenesis, skin-darkening and skin-aging. More particularly, the usage ofingredients and stilbenoids is shown to reduce the formation of melanin in melanocytes. The usage ofingredients and stilbenoids is also shown to reduce the generation of reactive oxygen species and oxidative free radicals. The use of-derived extracts or ingredients or stilbenoids is shown in the formulation of skin-protection, skin-whitening and/or anti-skin aging products.

Skin-protection composition containing dendrobium-based ingredients

The present invention relates to a polyphenol derivative of the stilbenoid family, namely trans-3,5,4'-trihydroxybibenzyl, also known as dihydro-resveratrol, as a remedial agent. In particular, the present invention presents the usage of dihydro-resveratrol as an anti-fibrotic agent in suppressing the activation of pancreatic stellate cells (PSCs). One embodiment of the present invention also relates to the management of pancreatic fibrosis, which is often accompanied with chronic pancreatitis and desmoplastic reaction of pancreatic cancer. Another embodiment of the present invention also has applications in preventing or alleviating or treating pancreatic cancer or pancreatogenic diabetes.

Method of using dihydro-resveratrol or its stilbenoid derivatives and/or chemical variants in treatments of fibrotic and diabetic conditions

A polyphenol derivative of the stilbenoid family, namely trans-3,5,4'-trihydroxybibenzyl, also known as dihydro-resveratrol, is disclosed as a remedial agent. In particular, the usage of dihydro-resveratrol as an anti-fibrotic agent in suppressing the activation of pancreatic stellate cells (PSCs) is presented. One embodiment also relates to the management of pancreatic fibrosis, which is often accompanied with chronic pancreatitis and desmoplastic reaction of pancreatic cancer. Another embodiment has applications in preventing or alleviating or treating pancreatic cancer or pancreatogenic diabetes.

The present invention relates to a method of using trans-3,5,4'-trihydroxybibenzyl, also known as dihydro-resveratrol for treating acute pancreatitis in a subject in needs thereof. More particularly, the present invention relates to a method of using dihydro-resveratrol, its derivatives and/or chemical variants as a remedial agent. The present invention particularly relates to the amelioration of tissue injury for the management of acute pancreatitis associated pulmonary injury of a subject.

Method of using dihydro-resveratrol for treating acute pancreatitis and associated pulmonary injury

A method for suppressing activation of pancreatic stellate cells of a subject includes administering a composition comprising a therapeutically effective amount of Eruberin A. A method of preventing, alleviating or treating pancreatic tumors or pancreatic tumors related diseases includes administering a composition comprising a therapeutically effective amount of Eruberin A. The Eruberin A may be extracted from

Use of a flavanol glycoside for suppressing activation of stellate cells

This invention relates to a Chinese medicinal formulation for the treatment of inflammatory bowel diseases, and a method of preparation thereof. The formulation comprises herbal components selected from a group consisting of Radix Codonopsis (Dangshen), Rhizoma Atractylodis Macrocephalae (Bai Zhu), Sclerotium Poriae Cocos (Fu Ling), Rhizoma Zingiberis Officinalis (Gan Jiang), Radix Paeoniae Alba (Bai Shao) and Rhizoma Coptidis (Huanglian).

Chinese medicinal formulation for treating inflammatory bowel disease and the preparation thereof

The present invention relates to a method of using an anthraquinone derivative namely 9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid, or known as Rhein, for treating chronic pancreatitis induced fibrosis of the pancreas. More particularly, the present invention relates to a method of using Rhein, its derivatives and/or chemical variants as an anti-fibrotic agent. The present invention particularly relates to the suppression of pancreatic stellate cell activation for the management of chronic inflammatory, fibrotic and tumorigenic pathologies in the pancreas.

Growing community of inventors

Hong Kong, China

Siu Wai Tsang