City University of Hong Kong

Siu-Pang Ng

Youngjin Lee

Chen Xu

Chi-Man Lawrence Wu

Abhimanyu Thakur

Guangyu Qiu

Tian Yang

A method of detecting one or more exosomal protein in a sample includes the steps of: a) introducing the sample on at least a part of a first sensor having a nanostructure thereon, subjecting the first sensor to an optical radiation in a certain spectral range to produce a localized surface plasmon resonance and measuring an induced phase response; and b) introducing the sample on a second sensor having a nanostructure thereon, and obtaining an image via atomic force microscopy analysis with a probe functionalized with an antibody targeting the exosomal protein. A kit for detecting at least one exosomal protein in a sample includes a first sensor having a nanostructure thereon; a second sensor having a nanostructure thereon, and a probe functionalized with an antibody targeting the exosomal protein.

Methods and kits for detecting exosomal protein

A sensor for liquid biopsy, its method of making, and its method of non-invasive use. The sensor includes a substrate with a surface functionalized with biotinylated antibodies. The biotinylated antibodies are arranged to engage with surface proteins on exosomes associated with malignant cancer cells such as glioma cells.

Sensor for liquid biopsy and its method of making, and method of non-invasive liquid biopsy

Growing community of inventors

Hong Kong, China

Siu-Pang Ng