Children's Medical Center Corporation

Beth Israel Deaconess Medical Center, Inc.

Children's Medical Center Corporation and Beth Israel

Deaconess Medical Center, Inc.

Sitaram Emani

Pedro J Del Nido

James D McCully

Douglas B Cowan

Sidney Levitsky

David M Hoganson

James E Lock

Peter E Hammer

Mossab Y Saeed

Audrey C Marshall

Christopher W Baird

The disclosure relates to compositions comprising isolated mitochondria or combined mitochondrial agents, and methods of treating disorders using such compositions.

Therapeutic use of mitochondria and combined mitochondrial agents

A repair device for closing a valve of a heart includes a main stem. The mains stem has a distal end and a proximal end. The main stem comprises a papillary anchor on the proximal end. The papillary anchor of the main stem is configured to attach to a papillary muscle of the heart. The main stem further includes a first branch extending from the main stem in a first direction and configured to attach to a first leaflet of the valve of the heart. The main stem also includes a second branch extending from the main stem in a second direction different from the first direction and configured to attach to a second leaflet of the valve. The first and second branches are flexible.

Repair device for heart valve repair

An expandable valve () and valve frame device that may be implanted within the body, for example, at a position of the heart. The device may be surgically implanted and subsequently expanded at a later time. The device may include an expandable sewing member () surrounding the valve frame () at a region between upstream and downstream ends of the device, for attaching the device to surrounding tissue. The device may include a membrane () for blocking leakage out the side of the valve frame between opposite ends. However, the membrane may include a side opening () for guiding fluid flow toward an appropriate anatomical outflow tract. The device may include a hood-like covering attached to a tissue wall, for smoothly receiving and guiding fluid flow along a perpendicular bend. The device may further include a flared opening at a downstream end, providing adequate space for device attachment.

Expandable stent valve

Therapeutic use of mitochondria and combined mitochondrial agent

Growing community of inventors

Newton, MA, United States of America

Sitaram Emani