Miles Laboratories, Inc.

Sisto Nicholas Stiso

Rodric H White-Stevens

William I White

Richard D Falb

Jerome Greyson

Chester L Sutula

Yung-Chyung Wang

A composition is disclosed for determining the ionic strength or specific gravity of an aqueous test sample, the composition comprising a strongly acidic or strongly basic polyelectrolyte, a buffer substance capable of providing a pH of about 5.5, and an indicator means capable of producing a detectable response to ion exchange between the polyelectrolyte and the sample. The test device comprises a carrier matrix incorporated with the test composition, and the method for its use comprises contacting an aqueous test sample with the device and observing a detectable response.

Composition, test device and method for determining the ionic strength

A test means for determining the ionic strength or specific gravity of an aqueous test sample, the test means comprising a weakly acidic or weakly basic polyelectrolyte which is at least partially neutralized, and an indicator means capable of producing a detectable response to ion exchange between the polyelectrolyte and the sample. The test device comprises a carrier matrix incorporated with the test means, and the method for its use comprises contacting an aqueous test sample with the device and observing a detectable response.

Test means, test device and method for determining the ionic strength or

A method and device for determining the specific gravity or osmolality of a liquid containing a nonionic, ionizable solute are disclosed. The method comprises contacting the liquid with an ionizing agent, thus converting the solute to ionized species in the liquid, and contacting the liquid with test means capable of producing a detectable response, such as a color response, dependent upon the specific gravity or osmolality of the ionized liquid. The composition comprises an ionizing agent capable, upon contact with the liquid, of ionizing the solute therein, and a test means capable, upon contacting the liquid containing the solute in ionized form, of producing a detectable response which is a function of the specific gravity or osmolality of the liquid. The device comprises a carrier matrix incorporated with the test means and the ionizing agent.

Method, composition and device for determining the specific gravity or

Devices and methods are provided for determining specific gravity or osmolality of liquids. The preferred devices comprise a carrier matrix incorporated with microcapsules having osmotically fragile, semipermeable polymeric membrane walls encapsulating therein a solute and a coloring substance. In use, the test device is contacted with the liquid to be tested, and color change on the carrier matrix is observed as a measure of the specific gravity or osmolality of the liquid.

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Elkhart, IN, United States of America

Sisto Nicholas Stiso