Valtion Teknillinen Tutkimuskeskus

Xyrofin Oy

Alko Group Ltd.

Alko-yhtiot Oy (alko Group Ltd.)

Sirkka Keranen

Merja Elisa Penttila

Marja T Paloheimo

Ulla Airaksinen

Kristiina Takkinen

Heikki Ojamo

Helena Nevalainen

Jonathan Knowles

Paivi Lehtovaara-Helenius

Tuula Teeri

Mats Walfridsson

Barbel Hahn-Hagerdal

Johan Hallborn

Sirpa Aho

Markku Aalto

Jonathan Kc Knowles

Eini Nyyssonen

Hans Ronne

Mika Outola

Sunee Nitisinprasert

Merja Penttila

This invention relates to recombinant-DNA-technology. Specifically, this invention relates to new recombinant yeast strains transformed with xylose reductase and/or xylitol dehydrogenase enzyme genes. A yeast strain transformed with the xylose reductase gene is capable of reducing xylose to xylitol and consequently of producing xylitol in vivo. If both of these genes are transformed into a yeast strain, the resultant strain is capable of producing ethanol on xylose containing medium during fermentation. Further, the said new yeast strains are capable of expressing the said two enzymes. Xylose reductase produced by these strains can be used in an enzymatic process for the production of xylitol in vitro.

Xylose utilization by recombinant yeasts

Increased production of secreted proteins by recombinant eukaryotic cells

Functional derivatives of endoglucanase I (EGI), and the cloning and recombinant expression thereof, are described.

Yeast strains producing cellulolytic enzymes and methods and means for

Methods for the production of recombinant immunoglobulins in a Trichoderma host are described.

Immunoglobulin production by trichoderma

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Helsinki, Finland

Sirkka Keranen