Norwegian University of Science and Technology

Siri Bachke

Marit Otterlei

The present invention provides an agent, or a composition containing an agent, for use in treating or preventing a bacterial infection in a subject, wherein said agent comprises: In certain aspects the agent and compositions of the invention may be used as single agents. In other aspects of the invention agents and compositions of the invention may be used in conjunction with one or more additional active agents, such as antibiotics.

Antimicrobial agents and their use in therapy

The present invention provides an agent, or a composition containing an agent, for use in treating or preventing a bacterial infection in a subject, wherein said agent comprises: (i) an oligopeptidic compound comprising a PCNA interacting motif and a domain that facilitates the cellular uptake of said compound, wherein the PCNA interacting motif is XXXXXX(SEQ ID NO: 1) and wherein: Xis a basic amino acid; Xis an aromatic amino acid; Xis an aromatic amino acid or a hydrophobic amino acid that has an R group comprising at least three carbon atoms; Xis an uncharged amino acid other than an aromatic amino acid, Glycine (G) and Proline (P); Xis any amino acid other than an acidic amino acid or an aromatic amino acid; and Xis any amino acid other than an acidic amino acid or an aromatic amino acid, preferably a basic amino acid or Proline (P), wherein when Xis not an aromatic amino acid, Xis not lysine (K) and Xis a basic amino acid or Proline (P); or (ii) a nucleic acid molecule comprising a sequence encoding the oligopeptidic compound of (i). In certain aspects the agent and composition of the invention may be used as single agents. In other aspects of the invention the agents and composition may be used in conjunction with one or more addition active agents, such as antibiotics, or in combination with UV radiation.

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Trondheim, Norway

Siri Bachke