Divergence, Inc.

Carnegie Institution of Washington

University of Massachusetts

SiQun Xu

Deryck Jeremy Williams

John D Bradley

Andrew P Kloek

Merry B McLaird

Jennifer A Davila-Aponte

Anita M Frevert

Craig C Mello

Andrew Fire

Samuel E Driver

Hiroaki Tabara

Mary K Montgomery

Lisa Timmons

Stephen A Kostas

Michelle Coutu Hresko

Catherine Baublite

Brandi J Chiapelli

Ronald E Worthington

Anita M Frevert-Thompson

Crag C Mello

A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.

Genetic inhibition by double-stranded RNA

Genetic inhibition of double-stranded RNA

Nucleic acid molecules from nematodes encoding phosphoethanolamine n-methyltransferase polypeptides are described. PEAMT-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of PEAMT-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators, as well as methods for antibody production.

Nematode phosphoethanolamine N-methyltransferase-like sequences

Nucleic acid molecules from nematodes encoding fatty acid desaturase polypeptides are described. Fatty acid desaturase-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of fatty acid desaturase-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators of fatty acid desaturase-like polypeptides, as well as methods for antibody production.

Nematode fatty acid desaturase-like sequences

Nucleic acid molecules from nematodes encoding PAN and ZP domain containing receptor polypeptides are described. PANZP polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of PANZP nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators, as well as methods for antibody production.

Nematode PAN and ZP receptor-like sequences

Growing community of inventors

Ballwin, MO, United States of America

SiQun Xu