Other

University of Florida Research Foundation Inc

Schering-plough Corporation

Pathogenes, Inc.

Siobhan Ellison

John B Dame

Charles A Yowell

William T Killeen

Methods for ameliorating neurodegenerative disorders and methods for ameliorating inflammatory disorders comprising administering to said subject an effective amount of a polypeptide comprising, in order from N-terminus to C-terminus, R-X-X-X-X-X-R′ wherein: R is optionally 1-5 additional α-amino acids of either L-configuration or D configuration; Xis any amino acid of either L-configuration or D-configuration; Xis any amino acid of either L-configuration or D-configuration; Xis Asp or Glu of either L-configuration or D-configuration; Xis any amino acid of either L-configuration or D-configuration; Xis any amino acid of either L-configuration or D-configuration; and R′ is optionally 1-5 additional α-amino acids of either L-configuration or D-configuration, with the proviso that at least three of X, X, X, X, and Xare of the D-configuration, wherein the N-terminus is optionally modified by acetylation, and wherein the C-terminus is optionally modified by amidation and/or methylation.

Therapeutic peptides and uses thereof

Acetylcholine and its receptors appeared in evolution before development of a nervous system. Cholinergic agonists functions include proliferation, differentiation, and cell-to-cell contact in protozoa] as well as vertebrate cells. Animal models for infection by Apicomplexan parasites require cell-to-cell contact followed by differentiation of parasite and host cells to produce clinical disease. Experimental infections are produced by introducing parasite infected leukocytes into a host. Binding cholinergic receptors on the parasites and leukocytes with levamisole HCl induces non-progressive infections and absence of signs of disease.

Method for screening drugs and animal model for same

The invention relates to a method of excysting and growing protozoal oocysts by in vitro tissue culture resulting in production of a continuous culture of merozoites. The invention also provides an economical and reliable supply of culturedsp. for vaccine production, assays and research. Domesticated avians that have been vaccinated using the proviedsp. are also provided.

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A gene encoding a 29 kilodalton protein found on the surface of merozoite stagehas been cloned and sequenced. The protein encoded by this gene, termed SnSAG-1, is an immunodominant antigen recognized on protein blots. Methods for using nucleic acids and polypeptides relating to SnSAG-1 in diagnostic tests and vaccine development are disclosed.

Detection of sarcocystis neurona

The invention relates to a method of excysting and growing protozoal oocysts by in vitro tissue culture resulting in production of a continuous culture of merozoites. The invention also provides an economical and reliable supply of culturedsp. for vaccine production, assays and research. Domesticatedthat have been vaccinated using the proviedsp. are also provided.

A gene encoding a 29 kilodalton protein found on the surface of merozoite stage has been cloned and sequenced. The protein encoded by this gene, termed SnSAG-1, is an immunodominant antigen recognized on protein blots. Methods for using nucleic acids and polypeptides relating to SnSAG-1 in diagnostic tests and vaccine development are disclosed.

An animal model for CNS infection by Apicomplexan parasites was produced by inoculating a homologous cell or other type of cell with the merozoite stage of the Apicomplexan parasite and inoculating the infected homologous cell or a cell line prepared therefrom back into the host from which it came. Such a model was used to develop drugs for treatment or prophylaxis, vaccines for protection from Apicomplexan diseases and diagnostic tests for determination active infection with Apicomplexan parasites.

Growing community of inventors

Fairfield, FL, United States of America

Siobhan Ellison