Corning Incorporated

Sinue Gomez-Mower

Steven Edward DeMartino

Robert Anthony Schaut

John Stephen Peanasky

James Ernest Webb

Joseph Michael Matusick

Patrick Joseph Cimo

Douglas Miles Noni, Jr

Connor Thomas O'Malley

Kevin Patrick McNelis

Amber Leigh Tremper

Christy Lynn Chapman

Jared Seaman Aaldenberg

Weirong Jiang

Christie Leigh McCarthy

Kristen Dae Waight

Eric Lewis Allington

Bryan James Musk

Adam Robert Sarafian

Shivani Rao Polasani

Michael Clement Ruotolo, Jr

Yuhui Jin

Kenneth Edward Hrdina

Kai Tod Paul Jarosch

Carlton Maurice Truesdale

Aize Li

Wei Sun

Tonia Havewala Fletcher

Daniel Arthur Sternquist

Dane Alphanso Christie

John Steele Abbott, Jr

Kelly Ann Murphy

Matthew Andrews Sevem

Tyler John Lucci

Madison Kathleen Tindle

Alicia Marie Gallagher

Michael Clement Ruotolo

John Steele Abbott Jr

A glass cartridge comprises a cylindrical body portion comprising an outer diameter Dand an average sidewall thickness T, the cylindrical body portion having a first end and a second end opposite the first end; an opening at the first end of the cylindrical body portion; a shoulder extending radially inward from the second end of the cylindrical body portion; and a neck extending from the shoulder and comprising an outer neck diameter Nthat is less than the outer diameter Dof the cylindrical body portion. The average wall thickness Tis less than or equal to 0.85*s, wherein sis a wall thickness of a standard glass cartridge defined by ISO 13926-1:2004 having an outer diameter dthat is closer to the outer diameter Dthan the outer diameter dof any other standard glass cartridge defined by ISO 13926-1:2004.

Glass containers for storing pharmaceutical compositions

The methods generally include contacting an alkali-containing glass article having a first alkali metal cation with a molten salt bath including from 0.1 wt. % to 3 wt. % nanoparticles and at least one alkali metal salt having a second alkali metal cation that has an atomic radius larger than an atomic radius of the first alkali metal cation. The nanoparticles may include at least one of metalloid oxide nanoparticles and metal oxide nanoparticles. The methods also include maintaining contact of the glass article with the molten salt bath to allow the first alkali metal cations to be exchanged with the second alkali metal cations of the molten salt bath. Further, the methods may include removing the glass article from contact with the molten salt bath to produce a strengthened glass article. A Surface Hydrolytic Resistance titration volume of the strengthened glass article may be less than 1.5 mL.

Salt bath compositions for strengthening glass articles, methods for using the salt bath compositions to strengthen glass articles, and glass articles strengthened thereby

Disclosed herein are glass pharmaceutical vials having sidewalls of reduced thickness. In embodiments, the glass pharmaceutical vial may include a glass body comprising a sidewall enclosing an interior volume. An outer diameter D of the glass body is equal to a diameter di of a glass vial of size X as defined by ISO 8362-1, wherein X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1. However, the sidewall of the glass pharmaceutical vial comprises an average wall thickness Tthat is less than or equal to 0.85*s, wherein sis a wall thickness of the glass vial of size X as defined by ISO 8362-1 and X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1.

Embodiments described herein are directed to compositions, systems, and processes for strengthening glass articles, which also minimize the concentration of decomposition products in the molten salt baths used in ion exchange processes to extend salt bath life and maintain the chemical durability of strengthened glass articles over time. The salt bath compositions may generally include from 90 wt. % to 99.9 wt. % of one or more alkali or metal salts and from 0.1 wt. % to 10 wt. % of silicic acid aggregates based on the total weight of the salt bath composition.

Salt bath compositions, salt bath systems, and processes for strengthening glass articles

Embodiments of the present disclosure are directed to salt bath systems for strengthening glass articles including a salt bath tank defining a first interior volume enclosed by at least one sidewall; a salt bath composition including an alkali metal salt positioned within the first interior volume; a containment device defining a second interior volume enclosed by at least one sidewall and including a regeneration medium positioned within the second interior volume; and a circulation device positioned proximate to an inlet of the containment device, wherein the circulation device is operable to circulate the salt bath composition through the containment device. Methods for regenerating a molten salt are also disclosed.

Salt bath systems for strengthening glass articles and methods for regenerating molten salt

Disclosed herein are glass pharmaceutical vials having sidewalls of reduced thickness. In embodiments, the glass pharmaceutical vial may include a glass body comprising a sidewall enclosing an interior volume. An outer diameter D of the glass body is equal to a diameter dof a glass vial of size X as defined by ISO 8362-1, wherein X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1. However, the sidewall of the glass pharmaceutical vial comprises an average wall thickness Tthat is less than or equal to 0.85*s, wherein sis a wall thickness of the glass vial of size X as defined by ISO 8362-1 and X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1.

Embodiments of the present disclosure are directed to methods for recycling waste ion exchange materials comprising a first alkali metal salt and a second alkali metal salt comprising reducing the size of the waste ion exchange materials to produce a plurality of waste ion exchange particles having particle sizes from 0.10 mm to 5.0 mm, and regenerating the plurality of waste ion exchange particles to produce a plurality of regenerated ion exchange particles having a concentration of the first alkali metal salt greater than a concentration of the first alkali metal salt in the waste ion exchange materials. Systems for recycling a waste ion exchange materials comprising a first alkali metal salt and a second alkali metal salt are also disclosed.

Systems and methods for recycling waste ion exchange materials

A sealed pharmaceutical container includes a shoulder, a neck extending from the shoulder, and a flange extending from the neck. The flange includes an inclined sealing surface defining an opening in the sealed pharmaceutical container. The sealed pharmaceutical container also includes a sealing assembly including a stopper extending over the sealing surface of the flange and a cap securing the stopper to the flange. The stopper has a glass transition temperature (T) that is greater than or equal to &#x2212;70&#xb0; C. and less than or equal to &#x2212;45&#xb0; C. The sealing assembly maintains a helium leakage rate of the sealed pharmaceutical container of less than or equal to 1.4&#xd7;10cm/s as the sealed pharmaceutical container is cooled to a temperature of less than or equal to &#x2212;45&#xb0; C.

Glass containers and sealing assemblies for maintaining seal integrity at low storage temperatures

Growing community of inventors

Corning, NY, United States of America

Sinue Gomez-Mower