F.i.s. Fabbrica Italiana Sintetici S.p.a.

Simone Zaramella

Ottorino De Lucchi

Siro Serafini

Stefano Tartaggia

Emiliano Rossi

Enrico Rosso

Object of the present invention is an improved process for the preparation of Elsicarbazepine and Eslicarbazepine acetate by means of chiral Ruthenium catalysts.

Process for the preparation of eslicarbazepine and eslicarbazepine acetate

An improved process for the preparation of a key intermediate for the synthesis of the active ingredient Omarigliptin is provided. The key intermediate is a compound having the following formula (I) wherein Ris propargyl or allyl group and P is an amine protecting group. The compound of formula (I) is prepared by converting a compound of formula (IV) by an amination reaction to a compound of formula (III), which is then protected to provide a compound of formula (II), which is then alkylated to provide the compound of formula (I).

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Vigodarzere, Italy

Simone Zaramella