Glaxo Group Limited

Convergence Pharmaceuticals Limited

Simone Spada

Giuseppe Alvaro

Maria Elvira Tranquillini

Romano Di Fabio

Daniele Andreotti

Simon Edward Ward

David Norton

Kevin Thewlis

Roberto Profeta

Jacqueline Anne Macritchie

Luca Arista

Francesca Cardullo

Alfredo Paio

Helen Susanne Price

Alessandro Pontiroli

Howard Robert Glaxosmithkline Marshall

Clive Leslie Glaxosmithkline Branch

Roderick Alan Glaxosmithkline Porter

Andrea Bozzoli

The invention relates to novel piperazine compounds of formula (I): to processes for their preparation; to pharmaceutical compositions containing the compounds; and to the use of the compounds in therapy to treat diseases for which blocking the Cav2.2 calcium channels is beneficial, i.e. in particular to treat pain.

Tricyclic substituted benzenesulfonamide piperazine derivatives as CAV2.2 calcium channel blockers

This invention relates to potentiation of the glutamate receptor by novel compounds of formula (I):  The invention also relates to the use of the derivatives in treating diseases and conditions mediated by potentiation of the glutamate receptor, compositions containing the derivatives and processes for their preparation.

Compounds which potentiate glutamate receptor and uses thereof in medicine

The present invention relates to piperidine derivatives of formula (I) specifically 2-(R)-(4-Fluoro-2-methyl-phenyl)-4-(S)-((8aS)-6-oxo-hexahydro-pyrrolo[1,2-a]-pyrazin-2-yl)-piperidine-1-carboxylic acid [1-(R)-(3,5-bis-trifluoromethyl-phenyl)-ethyl]-methylamide maleate and pharmaceutical compositions thereof, useful in the treatment of conditions mediated by tachykinins.

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The present invention relates to piperidine derivatives of formula (I): wherein R, R, R, R, R, R, R, X, Y, m and n are as defined herein; and pharmaceutically acceptable salts and solvates thereof; the process for their preparation and their use in the treatment of conditions mediated by tachykinins.

Piperidylcarboxamide derivatives and their use in the treatment of tachykinin-mediated diseases

The present invention relates to piperidine derivatives of formula (I):   The process for their preparation and their use in the treatment of a condition mediated by tachykinins.

Piperidine derivatives

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Verona, Italy

Simone Spada