Massachusetts Institute of Technology

Simone Schurle

Sangeeta N Bhatia

Gabriel A Kwong

Jaideep S Dudani

Piyush K Jain

The present disclosure relates to methods and products associated with in vitro and in vivo protease activity measurements and enzyme profiling. Some aspects of the present disclosure relate to measuring remotely triggered protease activity. In particular, the disclosure relates to methods of in vivo processing of exogenous molecules followed by detection of signature molecules as representative of the presence or absence of active enzymes associated with disease or conditions. The disclosure also relates to products, kits, and databases for use in the methods of the disclosure.

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Zurich, Switzerland

Simone Schurle