University of Minnesota

Newport Laboratories

Simone Oliveira

Randy R Simonson

Jonathan D Mahlberg

Tracy A Oleson

Mark D Titus

The present invention provides isolated polypeptides having oligopeptide permease activity and an amino acid sequence that has at least 80% identity with aOppA polypeptide. Also provided by the present invention are isolated polynucleotides that encode the polypeptides described herein, and antibody that specifically binds a polypeptide described herein. The present invention further provides genetically modified microbes, such as attenuatedstrains and other microbes that express polypeptides described herein. Also included are methods for using the polypeptides, polynucleotides, antibody, and genetically modified microbes.

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The present invention is a culture of cells ofexhibiting attenuated pathogenicity and capable of triggering a protective immune response when administered to pigs as a live vaccine. The present invention is also a method of preparing the cell culture, a method of preparing a vaccine from the cell culture, and a live vaccine based on the cell culture. The cell culture was modified from a pathogenic parent strain by MNNG mutagenesis and was selected by complete dependence on streptomycin for growth.

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New Brighton, MN, United States of America

Simone Oliveira