Dipharma Francis S.r.l.

Dipharma S.p.a.

Dr. Schar S.p.a.

Simone Mantegazza

Pietro Allegrini

Gabriele Razzetti

Graziano Castaldi

Vittorio Lucchini

Alberto Bologna

Roberto Rossi

Emanuele Attolino

Marcello Rasparini

Davide Brenna

Plietro Allegrini

Philippe Carboni

Niccolò Santillo

Maurizio Taddei

Diletta Naldini

Process for the preparation of known sulfonamides having antibacterial activity applicable on industrial scale, which allows their production in high yields and purity, comprising in particular the step of nucleophile aromatic substitution and oxidation in suitable conditions.

Process for the preparation of sulfonamide compounds

A process for the preparation of (R)-2-(3-diisopropylamino-1-phenylpropyl)-4-(hydroxymethyl)-phenol isobutyrate (Fesoterodine), its (S)-enantiomer, and novel intermediates useful in the synthesis.

Process for the preparation of fesoterodine

A process for the preparation of a compound of formula (I), or a salt thereof,  

Process for the preparation of pyridine-methylsulfinyl compounds

A process for the preparation of entacapone, in particular as the polymorphic form A, comprising the preparation of a compound of formula (V),  

Process for the preparation of entacapone

A novel process for the preparation of tolterodine, i.e. (R)&#x2014;N, N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine, in the racemic form, as well as intermediates useful for its preparation.

Process for the preparation of tolterodine

A novel process prepares tolterodine, i.e. (R)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine, in the racemic form, as well as intermediates useful for its preparation. Tolterodine free base may be prepared by reacting diisopropyl-(3-phenyl-3-p-tolyloxy-propyl)-amine and 60% aqueous sulfuric acid for three hours under stirring at room temperature. The reaction mixture is then poured over ice/water and then alkalized with 50% NaOH.

A process for the preparation of benzo[d]isoxazol-3-yl-methanesulfonic acid of formula (I), or a salt thereof, and the intermediates thereof, useful as an intermediate in the preparation of zonisamide.

Process for the preparation of benzo [d] isoxazol-3-yl-methanesulfonic acid and the intermediates thereof

A process for the preparation of benazepril hydrochloride (2) starting from the Michael adduct (14), obtained reacting compounds of formula (11) and (13), as defined in the disclosure

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Milan, Italy

Simone Mantegazza