Sigma-tau Industrie Farmaceutiche Riunite S.p.a.

Simona Sputore

Marco Frigerio

Giulio Carzana

Giuseppe Bianchi

Piero Melloni

Marco Santagostino

Patrizia Ferrari

Alberto Cerri

Mauro Gobbini

Marco Torri

Sergio De Munari

Elena Folpini

Silvia Armaroli

Maria Pia Zappavigna

Leonardo Banfi

Rosamaria Michaeletti

Fulvio Serra

Compounds of formula (I) wherein: the groups are as defined in the description, are useful for the preparation of medicaments for the treatment of cardiovascular disorders, in particular heart failure and hypertension. The compounds are inhibitors of the enzymatic activity of the Na, K-ATPase. Said compounds are used for the preparation of a medicament for the treatment of a disease caused by the hypertensive effects of endogenous ouabain, such as renal failure progression in autosomal dominant polycystic renal disease (ADPKD), preeclamptic hypertension and proteinuria and renal failure progression in patients with adducin polymorphisms. 

Amino derivatives of androstanes and androstenes as medicaments for cardiovascular disorders

An improved process is described for the preparation of compounds with general formula (I) and particularly for the preparation of the compound (E,Z) 3-(2-aminoethoxyimino)-androstane-6,17-dione, in which n&equals;1 and R &equals;R &equals;H

Process for the preparation of (E,Z) 3-(2-aminoethoxyimino)-androstane-6, 17-dione and its analogues

6-hydroxy and 6-oxo-androstane derivatives of formula (I), active on the cardiovascular system. ##STR1## wherein: the symbol A represents CH--OR, C.dbd.N--OR, CH--CH.dbd.N--OR and C.dbd.CH--N--OR; and R.sup.1, R.sup.2 and R.sup.3 are as defined herein.

6-Hydroxy and 6-oxo-androstane derivatives active on the cardiovascular

A process for the selective oxidation of a primary or secondary alcohol to an aldehyde or ketone and for the oxidation of a 1,2-diol to an .alpha.-ketol or .alpha.-diketone, which comprises contacting the alcohol or 1,2-diol with o-iodoxybenzoic acid. This process is suited for selective oxidation of alcohols containing easily oxidizable groups, such as amino or thioether groups and easily oxidizable heterocycles.

Process for the oxidation of primary and secondary alcohols to aldehydes

Growing community of inventors

Meda, Italy

Simona Sputore