Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa

Merck + Co., Inc.

Istituto Di Richerche Di Biologia Molecolare P. Angeletti S.p.a.

Irbm-science Park S.p.a.

C.n.c.c.s. Scarl Collezione Nazionale Dei Composti Chimici E Centro Screening

Simona Ponzi

Frank Narjes

Steven Harper

Jesus Maria Ontoria Ontoria

Vincenzo Summa

Joerg Habermann

Ian Stansfield

Stefania Colarusso

Uwe Koch

Cristina Gardelli

Federica Ferrigno

Savina Malancona

Ilaria Biancofiore

Giacomo Paonessa

Michael Rowley

Alessia Petrocchi

Marco Poma

Ester Muraglia

Emanuela Nizi

Victor Giulio Matassa

Immacolata Conte

Caterina Ercolani

Maria Del Rosario Rico Ferreira

Edith Monteagudo

Sergio Altamura

Alberto Bresciani

Claudio Giuliano

Ralph Laufer

Maria Veneziano

Alina Ciammaichella

Benjamin Gerlach

Maria Vittoria Orsale

Vicenzo Summa

The present invention relates to a class of novel heterocyclic compounds, to pharmaceutical compositions containing the compounds and their use in the treatment of kinetoplastid infections.

Compounds for use in the treatment of kinetoplastid infection

The present invention relates to compounds useful for treating parasitic diseases, which are infectious diseases caused or transmitted by a parasite. Compounds of the invention are particularly active against the causative pathogens in malaria. Such compounds are selective inhibitors of parasitic histone deacetylase (PfHDAC) and suppress the growth of parasites, such as, at a lower concentration than the concentration required for the inhibition of the growth of mammalian cells.

Compounds for use in the treatment of parasitic diseases

The present invention relates to tetracyclic thienopyrrole compounds of formula (I), wherein Ar, A, D1, D2, W, X, Y and Z are defined herein, and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising them, and their use for the treatment or prevention of infection by hepatitis C virus. 

Thienopyrroles as antiviral agents

The present invention relates to indole compounds of the formula (I): wherein R, R, R, R, A, E and X are as defined herein, and pharmaceutically acceptable salts thereof, useful in the prevention and treatment of hepatitis C infections. 

Indole derivatives as antiviral agents

The present invention relates to tetracyclic indole compounds of formula (I); wherein R, R, R, R, A, Ar, Y and Z are defined herein, and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising them, and their use for the treatment or prevention of infection by hepatitis C virus. 

Tetracyclic indole derivatives as antiviral agents

Compounds of formula (I), and pharmaceutically acceptable salts and esters thereof: (I); wherein Q, R2, X, Y and Z are as defined herein; are inhibitors of the hepatitis C virus (HCV) NS3 protease 

Peptides and their use as inhibitors of hepatitis C virus ns3 protease

A class of 2-aryl-4,5-dihydroxy-6-carboxypyrimidines of formula (I): wherein Ar is an optionally substituted aryl or heterocyclicgroup; as well as compounds of formula (I) which are derivatized at one or more of the 4-hydroxy, 5-hydroxy or 6-carboxy groups; and tautomers thereof, and pharmaceutically acceptable salts or esters thereof; and inhibitors of viral polymerases, especially the hepatitis C virus (HCV) polymerase enzyme 

Dihydroxypyridmidine carboxylic acids as viral polymerase inhibitors

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Rome, Italy

Simona Ponzi