Fondazione Centro San Raffaele Del Monte Tabor

Ifom Fondazione Istituto Firc Di Oncologia Molecolare

Ieo - Istituto Europeo Di Oncologia S.r.l.

Simona Polo

Paolo Lusso

Mario Varasi

Raffaella Amici

Ciro Mercurio

Giovanni Faga'

Elena Maspero

Sebastiano Pasqualato

Maurizio Pasi

Luca Sartori

The present invention relates to tricyclic derivatives of formula (I), which are useful as inhibitors of HECT-domain-containing E3 ligases, in particular NEDD4. The present invention also refers to pharmaceutical compositions comprising compounds of formula (I), to their medical use and to their process of preparation.

HECT E3 ligase inhibitors and uses thereof

RANTES mutants characterised by the substitution or addition of amino acids at the N-terminal of RANTES wild-type sequence and in the N-loop and/or 40's loop regions of RANTES wild-type sequence, and their use as anti-HIV, anti-allergic or anti-inflammatory agents.

RANTES mutants and therapeutic applications thereof

RANTES mutants characterized by the substitution or addition of amino acids at the N-terminal or RANTES wild-type sequence and in the N loop and/or 40&prime; loop regions of RNATES wild-type sequence, and their use as anti-HIV, anti-allergic or anti-inflammatory agents.

Rantes mutants and therapeutic applications thereof

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Milan, Italy

Simona Polo