Merial Limited

Meial Limited

Simona Barzu-Le-Roux

Jean-Christophe Francis Audonnet

Laurent Bernard Fischer

Laurent Bernard Fisher

Nathalie Michele Cachet

The present invention relates to a canine pre-proGHRH polypeptide, a canine mature GHRH peptide, an isolated polynucleotide which encodes the canine pre-proGHRH or the canine mature GHRH. The invention also encompasses vectors encoding and expressing the canine pre-proGHRH or the canine GHRH which can be used to treat disease and growth hormone deficiencies by gene therapy in vertebrates, in particular in dogs.

Canine GHRH gene, polypeptides and methods of use

DNA vaccine against a pathogen affecting farm animals, in particular bovines or porcines, comprising a plasmid containing a nucleotide sequence encoding an immunogen of a pathogen of the animal species considered, under conditions allowing the in vivo expression of this sequence, and a cationic lipid containing a quaternary ammonium salt, of formula in which R1 is a saturated or unsaturated linear aliphatic radical having 12 to 18 carbon atoms, R2 is another aliphatic radical containing 2 or 3 carbon atoms, and X a hydroxyl or amine group, this lipid being preferably DMRIE.

DNA vaccines for farm animals, in particular bovines and porcines

Improved vaccines or immunogenic or immunological compositions, and methods for making and using the same.

Growing community of inventors

Lentilly, France

Simona Barzu-Le-Roux