University College Cardiff Consultants Limited

Reviral Limited

Simon Ward

Paul John Beswick

Lewis Pennicott

Tristan Reuillon

Irina Chuckowree

Carolina Villalonga-Barber

Roderick Alan Porter

Neil Mathews

Stuart George Cockerill

Graham Lunn

Michael Paradowski

Jose Miguel Gascon Simorte

Stuart Cockerill

The invention provides compounds of the formula (I): (I) wherein A, A, R, R, B, B, X, X, n, a and b are as defined are defined in the specification, to pharmaceutical compositions comprising the compounds and the compounds for use as medicaments. The compounds potentiate AMPA receptor function and are expected to be useful in the treatment of central nervous system disorders, for example in the treatment of depressive disorders, mood disorders and cognitive dysfunction associated with neuropsychiatric disorders such as schizophrenia.

Compounds that modulates AMPA receptor function

The invention provides compounds of the formula (I): (I) wherein A, A, R, R, B, B, X, X, n, a and b are as defined are defined in the specification, to pharmaceutical compositions comprising the compounds and the compounds for use as medicaments. The compounds potentiate AMPA receptor function and are expected to be useful in the treatment of central nervous system disorders, for example in the treatment of depressive disorders, mood disorders and cognitive dysfunction associated with neuropsychiatric disorders such as schizophrenia. 

The invention provides compounds of the formula (I): wherein Rand Rare defined in the specification, to pharmaceutical compositions comprising the compounds and the compounds for use as medicaments. The compounds potentiate AMPA receptor function and are expected to be useful in the treatment of central nervous system disorders, for example in the treatment of depressive disorders, mood disorders and cognitive dysfunction associated with neuropsychiatric disorders such as schizophrenia. 

AMPA receptor potentiators

Benzimidazoles of formula (I): wherein: one of X and Y is an N atom or a substituted C atom, and the other is CH; L is a single bond, Calkylene, Calkenylene or Calkynylene; Ris Calkyl, Calkenyl, Calkynyl, 3- to 10-membered cycloalkyl, 5- to 10-membered heterocyclyl or 5- to 12-membered heteroaryl, each of which is unsubstituted or substituted; Z is halo, Chaloalkyl, nitro, &#x2014;CN, &#x2014;N(R)2, &#x2014;OR, &#x2014;SR, &#x2014;S(=0)R, or &#x2014;S(=0)R; each Ris independently hydrogen, Calkyl, Calkenyl or C2-6 alkynyl, wherein said alkyl, alkenyl and alkynyl groups are unsubstituted or substituted; and m is 0 or 1; and the pharmaceutically acceptable salt thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection. 

Spiro-indolines for the treatment and prophylaxis of respiratory syncytial virus infection (RSV)

Growing community of inventors

Cardiff, United Kingdom

Simon Ward