Boston Heart Foundation, Inc.

Linden Technologies, Inc.

Simon W Law

Robert S Lees

Ann M Lees

Anibal A Arjona

Tai-Nang Huang

Ming Shen

Yih Huang

Haisun Liao

Amy Anderson Deik

Natalia Mamaeva

Caroline Ngaara Woodward

Shin-Yih Chen

Isolated polynucleotides encoding novel polypeptides which are capable of binding to native and methylated LDL (low density lipoprotein), the isolated polypeptides, called LBPs (LDL binding proteins), and biologically active fragments and analogs thereof, are described. Also described are methods for determining if an animal is at risk for atherosclerosis, methods for evaluating an agent for use in treating atherosclerosis, methods for treating atherosclerosis, and methods for treating a cell having an abnormality in structure or metabolism of LBP. Pharmaceutical compositions and vaccine compositions are also provided.

Low density lipoprotein binding proteins and their use in diagnosing and treating atherosclerosis

Disclosed is an insoluble support that can be used, for example, for producing replicates of sample nucleic acids. The support includes a plurality of attached oligonucleotides that include a prokaryotic promoter sequence and a target annealing sequence 3' of the promote. The proximal end of the promoter sequence is spaced from the insoluble support by a distance greater than 10 nm.

Nucleic acid amplification

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Lexington, MA, United States of America

Simon W Law