Interleukin Genetics, Inc.

University of Texas System

Simon Van Dijk

Gordon W Duff

Barbara Dale Boyan

Kenneth S Kornman

David D Dean

Paul Martha

Paul M Martha, Jr

Diagnostics and therapeutics for osteoporosis, which are bases upon the identification of a subjects IL-1 haplotype and genotype pattern are described.

Diagnostics and therapeutics for osteoporosis

A method of predicting whether a subject is predisposed to developing early-onset menopause is provided. The method involves genotyping a patient at the IL-1 gene loci.

Methods of diagnosing early-onset menopause

Diagnostics and therapeutics for osteoporosis, which are based on the identification of the subject's IL-1 haplotype pattern are described.

The invention relates to the cloning and sequencing of the DNA encoding a membrane associated proteolipid from that is capable of inducing in vitro calcium binding. A proteolipid was extracted from cultures of and separated into a lipid component and three apoproteins having molecular weights of approximately 5.0, 5.5 and 7.5 kDa as determined by SDS-PAGE. The invention also includes the polyclonal and monoclonal antibodies directed against the membrane associated proteolipid and immunological assays developed with these antibodies.

Calcium binding proteolipid compositions and methods

The present invention relates to the cloning and sequencing of DNA encoding membrane-associated proteolipids from C. matruchotii to vectors comprising the DNA and to host cells containing vectors including the novelty DNA.

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San Antonio, TX, United States of America

Simon Van Dijk