Galderma Research & Development

Simon Trouille

Jean-Michel Bernardon

The invention concerns bi-aromatic compounds of formula (I) in which Ar represents (a), Z being O or S, Ris CH, &#x2014;CH&#x2014;O&#x2014;R, &#x2014;ORor &#x2014;COR; Ris &#x2014;OR, &#x2014;SRor a polyether radical if in the latter case Ris C-Calkyl and is in ortho or meta position relative to X&#x2014;Ar; Ris alkyl or Rand Rtogether form a cycle optionally interrupted by O or S; Ris aryl radical; Ris H, halogen, C-Calkyl or &#x2014;OR; Ris H, alkyl or &#x2014;COR; Ris H, alkyl, &#x2014;N(r')(r&#x2033;) or &#x2014;OR; Ris H, alkyl or &#x2014;COR; Ris alkyl; Ris H, C-Calkyl, alkenyl, monohydroxyalkyl or polyhydroxyalkyl, aryl or aralkyl or a sugar residue, r&#x2032; and r&#x2033; are H, alkyl mono- or polyhydroxyalkyl, aryl, an amino acid or sugar residue or together form a heterocycle, X represents a radical of formula (d) or (e) in which Ris H or &#x2014;OR; Ris H or alkyl; or Rand Rform an oxo radical, and the salts, optical and geometrical isomers of the compounds of formula (I).

Biaromatic compounds and pharmaceutical and cosmetic compositions comprising them

Biaromatic compounds connected by a propynylene or ailenylene bond, corresponding to the formula (I).

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Le Rouret, France

Simon Trouille