Imperial Chemical Industries Limited

Syngenta Corporation

David A. Roberts

Robin Wood

Arnold H. Ratcliffe

Keith Hopkinson Gibson

Simon T. Russell

Simon T Russell

David A Roberts

Robert J Pearce

Arnold H Ratcliffe

The invention concerns pharmaceutically useful novel compounds of the formula I, in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, Ra, A, X and Z have the various meanings defined herein, and their non-toxic salts, and pharmaceutical compositions containing them. The novel compounds are of value in treating conditions such as hypertension and congestive heart failure. The invention further concerns processes for the manufacture of the novel compounds and the use of the compounds in medical treatment. ##STR1##

Quinoline derivatives and use thereof as angiotensin II antagonists

The invention concerns novel heterocyclic compounds of the formula I as defined herein and their physiologically acceptable salts, together with pharmaceutical compositions containing them. The heterocyclic compounds antagonize the actions of angiotensin II and are of value in treating diseases or medical conditions such as hypertension and congestive heart failure in warm-blooded animals. The invention further includes processes for the manufacture of the novel compounds and their use in medical treatment.

Benz[4,5]imidazole-containing angiotensin antagonists

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Macclesfield, United Kingdom

Simon T Russell