Idorsia Pharmaceuticals Ltd

Actelion Pharmaceuticals Ltd

Simon Stamm

Francis Hubler

Dorte Renneberg

Kurt Hilpert

Bibia Heidmann

Romain Siegrist

Markus Von Raumer

John Gatfield

Thierry Kimmerlin

Olivier Bezencon

Mark Murphy

Sylvie Froidevaux

Amandine Fraichard

Charlyse Herrmann

Michael Ambuehl

Elvire Fournier

Oliver Geiseler

The present invention relates to derivatives of formula (I) wherein ring A, X, Y, Z, R, R, Rand Rare as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as C5a receptor modulators.

C5A receptor modulators

The present invention relates to derivatives of formula (I) wherein Ring A, X, Y, Z, R, R, R, Rand Rare as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as C5a receptor modulators.

Substituted tetrahydropyrazolo[3,4-d]pyrimidines and tetrahydropyrazolo[4,3-d]pyrimidines as C5A receptor modulators

The invention relates to compounds of formula (I) 

Triazole compounds as T-type calcium channel blockers

The invention relates to compounds of formula (I) wherein X, Y, R, R, (R), and (R)are as defined in the description, and to pharmaceutically acceptable salts of such compounds. These compounds are useful as calcium T-channel blockers.

Pyrazole compounds and their use as T-type calcium channel blockers

The invention relates to indole carboxamide derivatives of formula (I), wherein R, R, R, R, Rand Rare as defined in the description, their preparation and their use as pharmaceutically active compounds.

Indole carboxamide derivatives as P2X7 receptor antagonist

The invention relates to indole carboxamide derivatives of formula (I), wherein R, R, R, R, R, R, R, R, R, Rand n are as defined in the description, their preparation and their use as pharmaceutically active compounds.

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The invention relates to heterocyclic amide derivatives of formula (I), 

Heterocyclic amide derivatives as P2X7 receptor antagonists

The invention relates to heterocyclic amide derivatives of formula (I), wherein R, R, R, R, R, n, m, p and X are as defined in the description, their preparation and their use as pharmaceutically active compounds.

The invention relates to heterocyclic amide derivatives of formula (I), wherein R, R, R, R, n and X are as defined in the description, their preparation and their use as pharmaceutically active compounds.

The invention relates to heterocyclic amide derivatives of formula (I), wherein R, R, R, R, R, X, Y and n are as defined in the description, their preparation and their use as pharmaceutically active compounds. 

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Allschwil, Switzerland

Simon Stamm