Roche Diagnostics International Ag

Ypsomed Ag

Roche Diabetes Care, Inc.

Disetronic Licensing Ag

Other

Hoffmann-la Roche Inc.

F. Hoffmann-la Roche Ag

Roche Diagnostics Gmbh

Simon Scheurer

Christian Thalmann

Jürg Hirschel

Rudolf Zihlmann

Jürg Liniger

Martin Wyss

David Teutsch

Ulrich Haueter

Patrick Hostettler

Marcel Hunn

Christian Schrul

Florian Kuehni

Andreas Geipel

Joerg Dogwiler

Mario Bernhard

Markus Bütikofer

Patrik Denoth

Stefan Burren

Heiner Kaufmann

Reto Aeschlimann

Hanspeter Stoller

Torsten Kraft

Oliver Shergold

Kurt Friedli

Tom Walker

Daniel Peter

Sofia Galbraith

Thomas Buri

Florian Kühni

Bernhard Bigler

Christoph Jordi

Ruedi Zihlmann

Reto Schaltegger

Marc Oesch

Mark Roethlisberger

Markus Buetikofer

Juerg Liniger

Andreas Schneider

Sofia Elisabeth Galbraith

Roger Siegenthaler

Andres Mellenberger

Krista Kappeler

Bernhard Rytz

Marcel Both

Olivia Lepore

Dominik Scherrer

Thomas James Moy

Mike Unwin

Sofia Galbriath

Allen Pearson

Fabio Oester

Rudolf Zihlman

Simon Schuepbach

Jörg Dogwiller

Jörg Dogwiler

Simon Martin Bosshard

An injection device for dispensing a dose of a product by manually advancing a piston rod includes a dosing and dispensing mechanism having a housing with a longitudinal axis, a dosing sleeve mounted in the housing for adjusting and correcting the dose, a housing insert fixed to the housing and arranged inside the dosing sleeve, and a coupling sleeve mounted in the housing for driving the piston rod. For setting and correcting a dose, the dosing sleeve is rotatable relative to the coupling sleeve, and for dispensing the dose, the dosing sleeve can be coupled to the coupling sleeve in a rotationally fixed manner. In this case, the coupling sleeve has a locking element which can interact with the housing insert so that the coupling sleeve can be rotated in a first direction of rotation and cannot be rotated in a second direction of rotation relative to the housing insert.

Dosing system for an injection device

A needle insertion and retraction mechanism for a medication delivery device includes a housing and a needle carrier holding a needle guided by the housing and moved along a needle axis. A first spring member is adapted to move the carrier in an insertion direction. A second spring member is adapted to retract the carrier in a retraction direction, opposite the insertion direction. A control element, linearly guided by the housing, moves transversely to the needle axis from a starting position, via a needle insertion release position, to a needle retraction release position. When the control element is in its starting position, the control element is coupled to the carrier to prevent the carrier from moving in the insertion direction. When the control element is in the release position, the control element is decoupled from the carrier and the first spring member drives the carrier in the needle insertion direction.

Needle insertion and retraction mechanism

A dosing system for an injection device for dispensing a dose of a product includes a housing having a longitudinal axis, a dose-setting element, a holding element and a coupling sleeve for driving a driving device for dispensing the dose. The dose-setting element, holding element, and coupling sleeve may be accommodated in the housing. To set and correct the dose, the dose-setting element and the coupling sleeve move in the direction of the longitudinal axis relative to the housing, and the coupling sleeve may be held the holding element rotationally fixed by relative to the housing. To dispense the dose, the coupling sleeve may rotate relative to the housing, the dosing system including a guide in the housing, in which guide the holding element may be displaced in the direction of the longitudinal axis relative to the housing and be guided in a rotationally fixed manner relative to the housing.

An assembly for an injection or infusion device includes i) a cartridge being closed by a septum and the surface of the septum being sterile and covered by a first continuous flexible strip, and ii) a fluid path unit comprising a cartridge holder and a fluid path compartment comprising a needle in an interior, the needle is configured to penetrate the septum of the cartridge through a passage in the fluid path compartment. The passage is closed by a second continuous flexible strip keeping the interior of the fluid path compartment in a sterile condition. The cartridge is inserted into the cartridge holder aligning the septum with the passage and sandwiching both strips between the septum and the fluid path compartment. Both strips may be simultaneously removable from the cartridge and fluid path compartment thereby, establishing a sterile connection between the septum and the interior of the fluid path compartment.

Assembly for an injection or infustion device

Dosing device for an administration device with a limiting mechanism containing: a dosing sleeve with a first stop and a stop wheel with a second stop means adapted to continually and proportionally follow a movement of the dosing sleeve during dosing movements. During an ejection movement, there is no relative movement between dosing sleeve and stop wheel. The first stop and the second stop each describe a path curve by their movements such that the two path curves intersect in one point and the stops contact one another and tilt the stop wheel, thereby blocking the dosing movement of the dosing sleeve. The stop wheel comprises first and third sloped surfaces that may form first and second gear guidances with a clutch thereby returning the stop wheel to a non-tilted position during up or down dosing movements when the stops do not contact another.

Alternative device for adjusting a dosage with a limiting mechanism for a device for administering a product

A patch delivery device includes a bottom housing part, a delivery element for subcutaneous delivery of a liquid to a patient, an adhesive patch for attaching the bottom housing part to the skin of the patient, a capacitive sensor with an electrode configuration including a plurality of skin contact sensitive electrodes, and a release liner covering a patient-side adhesive layer of the adhesive patch prior to adhering to the patient's skin. The release liner includes an electrically conductive area extending over at least a portion of the electrode configuration of the capacitive sensor before being removed from the adhesive patch. Providing the release liner with a conductive area gives rise to a discernible change in capacitive response of the sensor electrodes upon release liner removal that enables sensing a removal of a release liner covering a patient-side adhesive layer prior to attachment to the skin of a patient.

Patch delivery device with skin contact sensor

Add-on for an injection device

A segmented piston rod for an injection device includes multiple segments joined together via a hinge located on one side of each segment. The piston rod can be bent in one direction by articulating subsequent hinges while an axial force can be transmitted by the segmented piston rod to the stopper when the subsequent hinges are closed and the segments abut each other opposite to the one side of the hinge. The segmented piston rod is secured against rotation relative to the housing around the longitudinal axis of the segmented piston rod. The segmented piston rod has a last element which abuts the stopper in the reservoir and a first segment which is opposite to the last segment. The first segment is includes an internal thread matching an external thread of a drive sleeve and rotation of the drive sleeve advances the piston rod towards the stopper of the reservoir.

Segmented piston rod for a medication delivery device

A coupling mechanism for a medication delivery device includes a first part axially fixed relative to a housing and rotatable around a longitudinal axis of the first part, the first part having a gearing engagement to a second part arranged along the longitudinal axis, the gearing engagement having a first frictional resistance. The second part axially moveable along the longitudinal axis, and directly or indirectly in a friction fit engagement with the housing, which has a second frictional resistance. The first frictional resistance being below the second frictional resistance such that a rotation of the first part in a first direction axially longitudinally moves the second part away from the first part and a rotation in a second direction, opposite to the first rotation direction, reduces the axial distance between the first and second part and/or axially moves the second part into coupling abutment with the first part.

Coupling mechanism for a medication delivery device

An infusion pump device and method for filling a fluidic system of the infusion pump with liquid medicament prior to infusion operation is presented. A control unit causes the infusion pump to: (a) bring a pump to an initial state; (b) switch a valve to a first state connecting a secondary reservoir to a first conduit and a primary reservoir; (c) retrieve medicament from the primary reservoir; (d) switch the valve to a second state connecting the secondary reservoir to a second downstream conduit; (e) expel the secondary reservoir contents into the second downstream conduit; (f) switch the valve to the first state; (g) retrieve the primary reservoir medicament; (h) switch the valve to the second state; and (i) expel the secondary reservoir contents into the second downstream conduit by shifting a piston to the initial position.

Infusion pump and method for improved filling of a fluidic system

At least one hand-held injection device for the metered injection of a liquid drug into a person's tissue is disclosed. The exemplary injection device comprises an elongated drug reservoir having a longitudinal reservoir axis (A), an elongated dosing unit having a dosing unit inlet, a dosing unit outlet, and a metering cavity, the dosing unit having a longitudinal dosing unit axis (A'), the elongated drug reservoir being fluidically coupled to the dosing unit inlet. The dosing unit and the drug reservoir are arranged such that the longitudinal dosing unit axis (A&#x2032;) is in parallel alignment with the reservoir axis (A). The dosing unit structured to allow the flow of the liquid drug from the drug reservoir into the metering cavity via the dosing unit inlet, thus charging the metering cavity, and to subsequently discharge the metering cavity by dosing drug out of the metering cavity into the dosing unit outlet.

Hand-held injection devices and methods of use

At least one dosing unit for an infusion pump is disclosed having a piston pump with a pump cylinder, a plunger arranged within said cylinder, and a plunger driving part provided for transmitting rotational torque from a driving unit to the plunger without itself being linearly displaced. The cylinder, the plunger and the plunger coupling element are coaxially arranged along a longitudinal axis and rotatable around said axis in regard to static parts of the dosing unit. The plunger and cylinder each having threads which engage with each other in such a way that a rotational movement of the plunger around the longitudinal axis results in a linear displacement of the plunger along the longitudinal axis. The dosing unit also having first coupling parts associated with the cylinder and second coupling parts associated with the plunger.

Dosing unit for an ambulatory infusion device

A dosing unit for an ambulatory infusion pump device is presented. The dosing unit comprises a cylinder pump with a cylinder and a piston arranged in the cylinder. The piston has a shaft with a first threaded segment interacting with a threaded portion of the cylinder and can be displaced along a longitudinal axis of the cylinder by rotating the piston in regard to the cylinder around the axis. Furthermore, the piston allows for the relative or absolute determination of the longitudinal and/or rotational displacement of the piston in regard to the cylinder. In one embodiment, the piston shaft comprises a second segment provided with optically detectable markings that allow the monitoring of the longitudinal and/or rotational displacement of the piston in regard to the cylinder.

Dosing unit for an infusion pump device

Infusion systems for pumping fluid into a body of a user, and methods for providing infusion systems, are disclosed. The infusion systems include an infusion pump, wherein the infusion pump comprises an infusion pump housing including a cavity. A fluid storage is removably inserted into the cavity of the infusion pump housing wherein, the fluid storage comprises a cartridge and an adapter connected to the cartridge such that the adapter encases the cartridge, and an infusion set is removably connected to the fluid storage.

Cartridge adapter for use in an infusion system

According to one embodiment, a cannula assembly may include a cannula module and an inserter module. In the pre-operational state the cannula is retracted with respect to the skin-contacting surface. In operational state the cannula projects beyond the skin-contacting surface. The inserter module may include an energy store and an activation mechanism. When the energy store is at least partially discharged, the stored potential energy is transformed to kinetic energy that moves the cannula from the pre-operational state to the operational state. The activation mechanism is triggerable from outside the cannula assembly with a trigger device. The activation mechanism prevents the energy store from being discharged before it is triggered by the trigger device, and enables the energy store to be discharged after it is triggered by the trigger device to force the cannula from the pre-operational state into the operational state.

Externally triggerable cannula assembly

Growing community of inventors

Bern, Switzerland

Simon Scheurer