Endomagnetics Limited

Michelson Diagnostics Limited

University of Houston System

Medisieve Ltd

University College London

Resonant Circuits Limited

Ucl Business Plc

Simon Richard Hattersley

Quentin Andrew Pankhurst

Peter Georg Laitenberger

Audrius Brazdeikis

George Charles Martin Frodsham

Richard Alan Wenman

Andrew Gilkes

Tiziano Agostinelli

Paul Southern

Adam Meekings

Daniel Woods

Jon Denis Holmes

David Steven Smith

Mathew Kallumadil

A method for detecting a magnetic marker comprises generating a driving magnetic field comprising first and second frequencies and detecting a response magnetic field comprising first and second response components. The magnetic marker provides a non-linear response to the driving signal. A primary portion of the response components is generated by the magnetic marker, and secondary portion of the response components is generated by a secondary magnetic source. The method comprises determining a driving factor representing a ratio of the frequencies in the driving signal; determining a correction factor corresponding to the secondary portion of the second response component, based on the first response component and the driving factor; determining a detection signal corresponding to the primary portion of the second response component, based on the second response component and the determined correction factor; and generating an output signal based on a strength of the detection signal.

Systems and methods for detecting magnetic markers for surgical guidance

A system and method for locating magnetic material. In one embodiment the system includes a magnetic probe; a power module in electrical communication with the magnetic probe to supply current to the magnetic probe; a sense module in electrical communication with the magnetic probe to receive signals from the magnetic probe; and a computer in electrical communication with the power module and the sense module. The computer generates a waveform that controls the supply of current from the power module and receives a signal from the sense module that indicates the presence of magnetic material. The magnetic probe is constructed from a material having a coefficient of thermal expansion of substantially 10/° C. or less and a Young's modulus of substantially 50 GPa or greater. In one embodiment magnetic nanoparticles are injected into a breast and the lymph nodes collecting the particles are detected with the probe and deemed sentinel nodes.

Magnetic probe apparatus

A hemofilter system. In one embodiment, the hemofilter system includes a container having a first surface, a second surface, and one or more wall surfaces, the first surface, the second surface and the one or more wall surfaces defining a volume; an input port in fluid communication with the first surface; an output port in fluid communication with the second surface; a filter bed comprising a plurality of planar magnetic meshes stacked in close juxtaposition and positioned within the container volume and coplanar with the first and second surfaces; a first magnet positioned on a first surface of the container; a second magnet positioned on the second surface of the container; a first input conduit in fluid communication with the input port; and a first output conduit in fluid communication with the output port. In another embodiment, the hemofilter system includes a pump in the input conduit.

Magnetic filter apparatus and method

A system and method for locating magnetic material. In one embodiment the system includes a magnetic probe; a power module in electrical communication with the magnetic probe to supply current to the magnetic probe; a sense module in electrical communication with the magnetic probe to receive signals from the magnetic probe; and a computer in electrical communication with the power module and the sense module. The computer generates a waveform that controls the supply of current from the power module and receives a signal from the sense module that indicates the presence of magnetic material. The magnetic probe is constructed from a material having a coefficient of thermal expansion of substantially 10/&#xb0; C. or less and a Young's modulus of substantially 50 GPa or greater. In one embodiment magnetic nanoparticles are injected into a breast and the lymph nodes collecting the particles are detected with the probe and deemed sentinel nodes.

A magnetic field generator. In one embodiment, the magnetic field generator includes a drive circuit including a MOSFET gate driver having an output terminal; a drive capacitor having a first and second terminal, a tank circuit including a tank circuit capacitor having a first and second terminal and a field-producing coil having a first and second terminal, wherein the first terminal of the tank circuit capacitor and the first terminal of the field-producing coil comprise the first terminal of the tank circuit, wherein the second terminal of the tank circuit capacitor and the second terminal of the field-producing coil comprise the second terminal of the tank circuit, wherein the first terminal of the drive capacitor is in electrical communication with the output terminal of the MOSFET gate driver, and wherein the second terminal of the drive capacitor is in electrical communication with the first terminal of the tank circuit.

Voltage source driver for a parallel resonant magnetic field generator

A method of processing optical coherence tomography (OCT) scans of a subject's skin (), the skin () having a surface (), the method comprising capturing a plurality of scans through the subject's skin (), the scans representing an OCT signal in slices through the user's skin () in parallel planes, the scans being offset from one another along a direction perpendicular to the parallel planes, the method comprising determining the position of the surface () of the skin () in each scan and displaying the scans to a user with an indication () indicative of a predetermined depth below the surface () of the skin () visible to the user.

Processing optical coherence tomography scans of a subjects skin

A detector circuit for a multi-channel interferometer, typically as may be used in an optical coherence tomography device, comprising: a plurality of measurement channels () each comprising a measurement detector (); and a balance channel () comprising a balance detector (), each of the measurement detectors () and the balance detector () having a light sensitive area and an electrical output configured to output a signal indicative of the intensity of light incident on the light sensitive area, in which each measurement channel () is provided with a feedback circuit () comprising: a variable gain circuit () having an input for the signal from the measurement detector () and an output, the variable gain circuit () being configured to output at its output the signal received at its input with a variable level of gain; a difference circuit () having a first input for the output of the variable gain circuit (), a second input for the signal from the balance detector () and an output, and being configured to output at its output a signal indicative of a difference of the signals at its first and second inputs; and a controller () for each variable gain circuit () configured to vary the variable level of gain dependent upon a low frequency component of the output of the difference circuit ().

Multiple measurement channel detector circuit for interferometers

A probe for detecting magnetic particles. In one embodiment, the probe includes: a cylindrical probe core having a first end and a second end, the cylindrical probe core defining two channels for containing coils of wire, one of the channels being adjacent the first end of the cylindrical probe core; two sense coils, one each of the sense coils being located in a respective one of the channels; and two drive coils, one each of the drive coils being co-located with the respective sense coil in a respective one of the channels.

Magnetic detector

A system and method for locating magnetic material. In one embodiment the system includes a magnetic probe; a power module in electrical communication with the magnetic probe to supply current to the magnetic probe; a sense module in electrical communication with the magnetic probe to receive signals from the magnetic probe; and a processing module in electrical communication with the power module and the sense module. The processing module generates a waveform that controls the supply of current from the power module and receives a signal from the sense module that indicates the presence of magnetic material. The magnetic probe is constructed from a material having a coefficient of thermal expansion of substantially 10/&#xb0; C. or less and a Young's modulus of substantially 50 GPa or greater. In one embodiment magnetic nanoparticles collect in the lymph nodes. In one embodiment the particles have a mean hydrodynamic diameter of between 5-200 nm.

A probe and method for detecting magnetic particles. In one embodiment, the probe includes a probe core having a first end and a second end, the probe core defining two regions for containing coils of wire, one of the regions being adjacent the first end of the cylindrical probe core; two sense coils, one each of the sense coils being located in a respective one of the regions; and two drive coils, one each of the drive coils being located in a respective one of the regions, wherein the regions are separated by a distance equal to or greater than the diameter of one of the coils and a source of a secondary magnetic drive field. In another embodiment, the frequency of the drive signal of the secondary magnetic drive field is less than the frequency of the drive signal of the primary drive coils.

Apparatus for determining magnetic properties of materials comprises a portable probe (), an equipment trolley () holding cryogenics and electronics and connecting cables (). The probe () comprises a drive coil () and a correction coil (), the drive coil () being disposed symmetrically with respect to an inner second-order gradiometer sensor coil (). Electrical connectors in the form of 2-meter long Belden (1192A) microphone cables () are used to connect the apparatus on the equipment trolley () to the drive coil (), the correction coil () and the sensor coil (). The drive coil () is driven so as to generate a sinusoidally varying magnetic field. The electronics comprise a flux-locked loop (), a SQUID controller (), a data acquisition module (), which captures and processes the signals and a computer (). A liquid-nitrogen dewar () is supported on the equipment trolley () and houses a sensitive SQUID detector () and a transfer coil () made from copper. Possible applications of the apparatus include an intra-operative tool for sentinel lymph node detection in the treatment of breast cancer, and a non-destructive evaluation tool for detecting voids and defects in aluminum and applications in the aeronautics industry.

Apparatus and method for determining magnetic properties of materials

A multi-beam interferometer, typically for use in Optical Coherence Tomography, comprising a multiple beam source, the source being arranged so as to provide, in use, a plurality of beams of light for use in the interferometer, the source comprising: a light source arranged to, in use, emit a beam of light; and a rattle plate comprising a first reflective surface and a second reflective surface facing one another, the second reflective surface being only partially reflective.

Growing community of inventors

Kent, United Kingdom

Simon Richard Hattersley