Genentech, Inc.

Simon-Peter Williams

Yvonne M Chen

Jane Louise Grogan

Matthew Lawrence Albert

Eugene Yu-Chuan Chiang

Provided are anti-CD8 antibodies that bind human CD8 and do not stimulate or inhibit the activation of CD8T cells. Also provided are nucleic acids encoding such anti-CD8 antibodies, vectors comprising such nucleic acids, host cells comprising same, and methods of making such anti-CD8 antibodies. Also provided are anti-CD8 antibodies conjugated to a detectable label. Provided are methods of using such anti-CD8 antibodies to detect CD8T cells in a subject, monitor disease progress in a subject having cancer, and monitor treatment progress in a subject having cancer.

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Redwood City, CA, United States of America

Simon-Peter Williams