Pfizer Corporation

Simon Paul Planken

Asako Nagata

Hengmiao Cheng

Sajiv Krishnan Nair

Scott Channing Sutton

Jillian Elyse Spangler

Cynthia Louise Palmer

John Charles Kath

Andreas Maderna

Michael Raymond Collins

Theodore Otto Johnson, Jr

Ping Chen

Maria Angelica Linton

Alexei Brooun

Elizabeth Ann Lunney

Liming Huang

Song Liu

Douglas Carl Behenna

Benjamin Joseph Burke

Sujin Cho-Schultz

Kevin Kun-Chin Liu

Rongliang Chen

Jacob Cole Deforest

Shouliang Yang

Hanna Maria Wisniewska

Theodore Otto Johnson

Theodore Otto Johnson Jr

The invention relates to compounds of Formula (I)-(III) and pharmaceutically acceptable salts thereof to their use in medicine; to compositions containing them; to processes for their preparation; and to intermediates used in such processes. The compounds the present invention may be useful in the treatment, prevention, suppression and amelioration diseases, disorders and conditions such as cancers.

Pyrido[4,3-d]pyrimidine compounds

Compounds of the general formula: processes for the preparation of these compounds, compositions containing these compounds, and administration of these compounds to patients to treat pancreatic, lung, colon and other cancers.

Substituted quinazoline and pyridopyrimidine derivatives useful as anticancer agents

Compounds of the general formula: processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

Tetrahydroquinazoline derivatives useful as anticancer agents

The present invention relates to compounds of formula (I) 

Purine derivatives

The present application relates to compounds of Formula (I), and Formula (II), or pharmaceutically acceptable salt thereof, wherein A, X, Y, Z, e, f, R, R, R, R, R, R, R, R, R, R, R, R, R, R, Rand Rare defined herein. These novel pyridine derivatives that are useful in therapy, in particular for treating diseases or conditions mediated by Smo, including the treatment of abnormal cell growth, such as cancer, in mammals. Additional embodiments relate to methods of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds. 

Pyridine-2-derivatives as smoothened receptor modulators

Pyrrolopyrimidine and purine derivatives

The present invention relates to compounds of formula (I), or a pharmaceutically acceptable salt or solvate thereof, wherein: R, R, Z, t, and ring A are as defined in the specification. The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) and methods of treating a condition that is mediated by the modulation of JNK, such as diabetes, the method comprising administering to a mammal an effective amount of a compound of formula (I). 

Substituted 2-amino-fused heterocyclic compounds

The present invention provides compounds of formula (I), or pharmaceutically acceptable salts or solvates thereof, methods for their preparation, methods for their use, and pharmaceutical formulations comprising them.

Therapeutic compounds

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San Diego, CA, United States of America

Simon Paul Planken