Lantheus Medical Imaging, Inc.

Bristol-myers Squibb Pharma Company

Other

Bristol-myers Squibb Compnay

Bristol Meyers Squibb Company

Simon P Robinson

David C Onthank

Nhung Tuyet Nguyen

David S Casebier

Robert W Siegler

Heike S Radeke

Ajay Purohit

Tarakeshwar Vishwanath Anklekar

Charles Chester Van Kirk

Thomas David Harris

Richard R Cesati

Michael T Azure

Ming Yu

Edward H Cheesman

Richard J Looby

Padmaja Yalamanchili

Joel Lazewatsky

Douglas Dischino

Suresh K Pandey

George L Trainor

Robert F Kaltenbach

Mikhail Kagan

Carol Walker

Thomas D Harris

Carol Hui Hu

Matthias Broekema

Douglas D Dischino

Douglas D Dischimo

W Siegler Robert

A method of imaging, the method comprising administering, to a subject, a compound of Structure Alpha, of the formula:

Ligands for imaging cardiac innervation

The invention provides, inter alia, improved lipid formulations used to generate lipid-encapsulated gas microspheres, and methods of their use.

Lipid-encapsulated gas microsphere compositions and related methods

Provided herein are improved methods for preparing phospholipid formulations including phospholipid UCA formulations.

Methods for making ultrasound contrast agents

Provided herein are methods and devices for identifying and/or distinguishing UCA formulations and specifically activating such formulations to produce UCA suitable for in vivo use.

Methods and devices for preparation of ultrasound contrast agents

The present invention provides compounds with imaging moieties for imaging a subject. The present invention also relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, a composition or plurality of imaging agents is enriched inF. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs.

Compositions, methods, and systems for the synthesis and use of imaging agents

Novel compounds that find use as imaging agents within nuclear medicine applications (PET imaging) for imaging of cardiac innervation are disclosed. These PET based radiotracers may exhibit increased stability, decreased NE release thereby reducing side effects, improved quantitative data, and/or high affinity for VMAT over prior radiotracers. In some instances the compounds are developed by derivatizing certain compounds with 18F in a variety of positions: aryl, alkyl, a keto, benzylic, beta-alkylethers, gamma-propylalkylethers and beta-proplylalkylethers. Alternatively or additionally, a methyl group a is added to the amine, and/or the catechol functionality is either eliminated or masked as a way of making these compounds more stable.

The present disclosure is directed, in part, to compounds and methods for imaging myocardial perfusion, comprising administering to a patient a contrast agent which comprises a compound that binds MC-1, and an imaging moiety, and scanning the patient using diagnostic imaging.

Contrast agents for myocardial perfusion imaging

Growing community of inventors

Stow, MA, United States of America

Simon P Robinson