Novo Nordisk A/s

Simon Munch Pedersen

Simon Roervig

Steffen Hansen

Bo Radmer

Christian Plambech

Jesper Peter Windum

Christian Hoejris Nielsen

Morten Revsgaard Frederiksen

Brian Mouridsen

Lars Eilertsen

Willem Van Der Beek

Roger Harrington

Ruben Archilla

Kurt Solgaard

Carsten Soerensen

Soeren Dyring Jensen

Mattias Ingerslev

Christian Højris Nielsen

Torben Strøm Hansen

Rasmus Kann Jensen

Søren Dyring Jensen

Simon RØRVIG

Rubén Archilla

Carsten SØRENSEN

The invention relates to a prefilled injection pen for apportioning multiple set doses of a liquid drug. The injection pen comprises a housing assembly with a removable cap rotatable coupled to the housing assembly such that the user has to rotate the removable cap upon mounting and dismounting the removable cap. Rotation of the removable cap initiates a process in which the proximal end of a needle cannula is first inserted into a cartridge permanently embedded in the housing assembly and thereafter moves the cartridge proximally to thereby pump a predetermined amount of the preservative containing liquid drug from the cartridge and into a cleaning chamber carried by an axially movable shield. The needle cannula is mounted in a needle hub which is arranged to follow rotation of the removable cap and guided helically in relation to the housing assembly such that the needle hub is moved proximally upon rotation of the removable cap. Further, the axially movable shield is operated by the needle hub to follow proximal movement of the needle hub such that the distal tip of the needle cannula is maintained inside the cleaning chamber upon axil movement of the needle hub and the needle cannula.

Medical injection device with needle cleaning

The invention relates to a piston rod drive arrangement for an injection device used for self-administration of a plurality of individually set doses. The drive arrangement is made from a first element () mating the non-circular cross-section () of a piston rod () and a second element () having an inner thread () mating the outer thread of the piston rod. Whenever the first element () and the second element () are rotated in relation to each other the piston rod () is moved in an axial direction. In order to minimise the play in the threaded connection a resilient element () is proved to apply a force to the piston rod () in a longitudinal direction.

Piston rod drive for an injection device

The invention relates to a non-axial working End-of-Content mechanism which is geared by a hypocycloid gearing. The EoC mechanism comprises a first element () having a first internal surface () with a first internal diameter (D), and an EoC element () having a second external surface () with a second external diameter (d) being smaller that the first internal diameter (D). The EoC element () is located inside the first internal diameter (D) of the first element () and the first element () and the EoC element rotates relatively to each other in a gearing ratio. The EoC element () thus operating as the inner rolling circle of a hypocycloid counting the numbers of relative rotations. The EoC mechanism further has stopping means ()) provided for stopping the relative rotation in a predetermined position which position correlates to the initial injectable content of drug in the injection device such that a user cannot at any time set a dose larger than the quantum left in the injection device at any time.

Non-axial working end-of content mechanism and an injection device comprising the same

The invention relates to a torsion spring driven injection device having a dial-down mechanism for dialling down a selected dose size. The torsion spring () is strained when setting a dose by rotating a proximally located dose setting button() relatively to the housing in a first direction and unstained when rotating the same dose setting button () in a second direction opposite the first direction. In order to secure the torsion spring () in its strained position a one-way ratchet mechanism is provided. This one-way ratchet mechanism comprises a fixation element () coupled to the housing and having a toothing () and a ratchet element () having at least one ratchet arm () engaging the fixation element () and which ratchet element () is operational coupled to the dose setting button (). The dose setting button () directly engages the at least one ratchet arm () when the dose setting button () is rotated in the second direction which releases the at least one ratchet arm () from the toothing () of the fixation element () and allows the ratchet element () to rotate relatively to the fixation element () in the second direction under influence of the torsion spring ().

Dial-down mechanism for wind-up pen

The present invention relates to an injection device for automatic spring driven injection of a liquid drug. The injection device has a dose setting mechanism by which doses of an individual size can be set by a user, and a mechanical dose size display for displaying the size of the set dose. The scale drum () is coupled to a rotatable dose dial button () which is axially retained in relation to the housing () and by which the individual doses can be set.

Injection device with a sliding scale

The present invention relates to an injection device for automatic torsion spring driven injection of a liquid drug. The injection device is of the type wherein a telescopically movable needle shield activates the release of the torque of the torsion spring to drive the injection when the needle shield is moved from its extended position to a retracted position. The injection device further has a needle holder carrying the injection needle, which needle holder is axially movable both in relation to the housing and in relation to the needle shield. It is therefore possible to retract the needle shield in relation to the housing and at the same time move the needle holder to its extended position such that the injection needle is presented outside the needle shield thereby providing for easy exchange of the injection needle.

Spring driven injection device

The present invention relates to a torsion spring driven injection device for delivering multiple set doses of a liquid drug from a cartridge by moving a plunger forward inside the cartridge. The torsion spring () applies a rotational torque onto a drive member () engaging a piston rod () which is then driven forward by this rotation. The piston rod driver can be coupled and de-coupled from the torsion spring mechanism. In the de-coupled position, the piston rod driver is freely rotatable and can thus rotate if the piston rod is moved axially. A further torsion arrangement () is preferably provided such that a torque is build up between the piston rod driver and the housing whenever the piston rod is moved backwards. This torsion arrangement urges the piston rod driver to rotate in a direction bringing the piston rod forward into abutment with the plunger.

The present invention relates to medicament injection devices (). A cartridge () with a septum and a needle unit () having front and rear needles () are configured for relative movement from a state where the septum is sealed to a state where the septum is pierced by the rear needle (). The injection device () may include a needle shield () and be configured for piercing the septum by the rear needle () when the front needle () is operated relative to the needle shield (). The injection device () may also include a damping mechanism configured for limiting the speed of movement of the cartridge relative to the needle unit. The injection device () may also include an indicator generating a signal when a piston driver has travelled the complete stroke length, wherein the indicator has a deflection element that is deflected prior to or during movement of the cartridge relative to the housing.

Medical injection device

The present invention relates to an injection device for automatic torsion spring driven injection of a liquid drug. The injection device is of the type wherein a telescopically movable needle shield () activates the release of the torque of the torsion spring to drive the injection when the needle shield is moved from its extended position to a retracted position. The injection device is provided with a needle interface () carrying the injection needle, which needle interface is provided with means () preventing axial movement of the shield when no injection needle is mounted. Further, other means are provided to restrain the needle shield in the retracted position when the injection device is its 'zero' position such that a user has access to the injection needle in order to exchange the injection needle.

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Copenhagen, Denmark

Simon Munch Pedersen