Ausculsciences, Inc.

Simon Martin

Brady Nicholas Laska

Sergey A Telenkov

Md Shahidul Islam

Daniel Labonté

Robert J Griffin

Jikang Zeng

Jun Zhou

Mark W Armstrong

Steven P Morton

Camilla Jastrzebski

David Gloag

Anthony Dewar

At least one sound generator operatively coupleable to a corresponding at least one auscultatory sound-or-vibration sensor provides for generating a corresponding at least one sound signal that is applied to the corresponding at least one auscultatory sound-or-vibration sensor. For each sound generator and corresponding auscultatory sound-or-vibration sensor operatively coupled thereto, a communications interface provides for receiving a corresponding auscultatory sound signal from the corresponding auscultatory sound-or-vibration sensor, and at least one computer processor operatively coupled to the communications interface provides for either generating, or causing to be generated, an electronic audio signal that drives the sound generator, causing a corresponding at least one sound signal to be generated thereby, and at least one computer processor provides for analyzing the auscultatory sound signal from the corresponding auscultatory sound-or-vibration sensor responsive thereto for determining whether or not the corresponding at least one auscultatory sound-or-vibration sensor is functioning properly.

Coronary artery disease detection signal processing system and method

A metallic diaphragm disk incorporating a piezoelectric material bonded thereto and operatively coupled to a base rim of a housing provides for closing an open-ended cavity at the first end of the housing. At least one inertial mass is either incorporated in or attached to the housing. A plastic film adhesively bonded to at least one of an outer rim of the housing or an outer-facing surface of the disk provides for receiving an adhesive acoustic interface material to provide for coupling the housing to the skin of a test subject.

Auscultatory sound-or-vibration sensor

An auscultatory sound-or-vibration sensor electronic test signal applied to a sound generator generates an acoustic sound signal, responsive to which an auscultatory sound-or-vibration sensor in proximity to the sound generator generates a corresponding auscultatory sound signal. The auscultatory sound-or-vibration sensor electronic test signal incorporates a plurality of frequency components, each frequency component of which incorporates an integral number of wavelengths and is terminated following a duration of time corresponding to the integral number of wavelengths after that frequency component is applied to the corresponding sound generator. A determination of whether or not the auscultatory sound-or-vibration sensor is functioning properly is made responsive to an analysis of a Fourier Transform of the auscultatory sound signal.

Each conductor of a plurality of insulated conductors of a wiring harness extends between, and electrically connects, a corresponding terminal of a first electrical connector to either a corresponding terminal of an electrical connector jack of a plurality of electrical jacks located along the wiring harness, or to a corresponding terminal of a corresponding auscultatory sound-or-vibration sensor of the plurality of auscultatory sound-or-vibration sensors. The plurality of insulated conductors are organized in a plurality of distinct branches, each distinct branch originating either from the first electrical connector or from another portion of the wiring harness, and the locations of the plurality of distinct branches, in cooperation with the plurality of electrical jacks, if present, are implicitly suggestive of a corresponding location of the corresponding auscultatory sound-or-vibration sensor on a thorax of a test subject.

Wiring harness for use with auscultatory sound-or-vibration sensors

At least one of at least one data-dependent scale factor or at least one data-dependent detection threshold is determined responsive to at least one block of time-series data of an auscultatory-sound signal generated by an auscultatory-sound sensor operatively coupled to a portion of the skin of a test-subject, wherein the at least one data-dependent scale factor or at least one data-dependent detection threshold provides a measure of a range of values of the at least one block of time-series data in relation to a predetermined metric, and is used to determine whether or not the auscultatory-sound sensor is either debonded or detached from the skin of the test-subject.

System and method for detecting decoupling of an auscultatory sound sensor from a test-subject

An auscultatory sound signal acquired by a recording module is coupled through a high-pass filter having a cut-off frequency in the range of 3 to 15 Hz and subsequently filtered with a low-pass filter, and optionally subject to variable-gain amplification under external control&#x2014;via a USB or wireless interface&#x2014;of an associated docking system, responsive to the resulting processed auscultatory sound signal. A sound generator in the docking system generates an associated test signal having an integral number of wavelengths for each of a plurality of frequencies. The test signal is applied to a corresponding auscultatory sound-or-vibration sensor to test the integrity thereof. Resulting sound signals recorded by the recording module are analyzed using a Fourier Transform to determine sensor integrity.

A time-series array of noise data is generated from an inverse frequency transform of the product of the frequency spectrum of an auscultatory sound signal with an associated noise filter generated responsive to a cross-correlation of frequency spectra of auscultatory sound signals from adjacent auscultatory sound-or-vibration sensors on the torso of a test subject. Noise power within at least one range of frequencies of average of frequency spectra from a plurality of windows of the time-series array of noise data is compared with a threshold to determine whether or not the associated auscultatory sound-or-vibration sensor is excessively noisy. In one embodiment, the noise filter is generated by subtracting from unity, a unity-normalized cross-correlation of frequency spectra of the auscultatory sound signals, wherein the resulting values are clipped so as to be no less than an associated noise floor.

Method of detecting noise in auscultatory sound signals of a coronary-artery-disease detection system

A metallic diaphragm disk incorporating a piezoelectric material bonded thereto and operatively coupled to a base rim of a housing provides for closing an open-ended cavity at the first end of the housing. In one aspect, plastic film adhesively bonded to at least one of an outer rim of the housing or an outer-facing surface of the disk provides for receiving an adhesive acoustic interface material to provide for coupling the housing to the skin of a test subject. In another aspect, an outer-facing surface of a base portion of the housing provides for receiving an adhesive acoustic interface material to provide for coupling the housing to the skin of a test subject, at least one inertial mass is operatively coupled to a central portion of the metallic diaphragm disk, and the opening in the first end of the housing is closed with a cover.

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Gatineau, Canada

Simon Martin