Biocompatibles UK Limited

Abbott Laboratories Corporation

Simon Leppard

Andrew Lennard Lewis

Peter William Stratford

Brenda Hall

Maria Victoria Fajardo Gonzalez

Pedro Garcia

A composition for chemoembolotherapy of solid tumors comprises particles of a water-insoluble water-swellable synthetic anionic polymer and, absorbed therein an anthracycline. Suitably the polymer is a poly(vinyl alcohol) based polymer and the drug is doxorubicin.

Chemoembolisation

It is provided an intravascular stent comprising a metal body and a coating comprising a polymer and a restenosis inhibiting agent in which the restenosis inhibiting agent is a sparingly water soluble drug and the polymer in the coating is a cross-linked amphiphilic polymer, wherein the amphiphilic polymer comprises groups conferring hydrophobicity and groups conferring hydrophilicity.

Stents with drug-containing amphiphilic polymer coating

It is provided a method for producing a drug coated intravascular stent comprising coating a stent body with a cross-linkable amphiphilic polymer.

An initiator for the terminal group of the polymer product of an atom or group radical transfer polymerisation has an activated carboxyl or an amine group which is reacted with an amine or carboxyl (respectively) group containing biologically active compound. The initiator is preferably 4-(3-(2-bromo, 2-methyl-propionate)phenyl)-propionic acid N-hydroxysuccinimide ester or 2-bromo, 2-methyl-propionic acid N-hydroxysuccinimide ester. The monomers preferably comprise a zwitterionic monomer such as 2-methacryloxyethyl-2'-trimethyl ammoniumethyl phosphate inner salt.

Conjugation reactions

A vascular stent having an amphiphilic polymer coating is loaded with a restenosis inhibiting agent, which is sparingly soluble in water, whereby delayed release of the agent takes place after implantation of the stent.

A composition for chemoembolotherapy of solid tumours comprises particles of a water-insoluble water-swellable synthetic anionic polymer and, absorbed therein an anthracycline. Suitably the polymer is a poly(vinyl alcohol) based polymer and the drug is doxorubicin.

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Surrey, United Kingdom

Simon Leppard