Antabio Sas

Simon Leiris

David Thomas Davies

Martin Everett

Nicolas Sprynski

Thomas David Pallin

David Edward Clark

Richard Leonard Elliott

Toby Jonathan Blench

Lilha Beyria

Andrew Peter Cridland

Magdalena Zalacain

Jonathan Mark Sutton

Michael Steven Bodnarchuk

The invention relates to a compound which is a diazabicyclooctanone of Formula (I) or a pharmaceutically acceptable salt thereof: wherein R is as defined herein. The compounds are useful in the treatment of bacterial infection, in particular they are useful in reducing bacterial resistance to antibiotics. They are also useful in the treatment of bacteria which express serine-β-lactamase enzymes, in combination with antibiotics.

Diazabicyclooctanones as inhibitors of serine β-lactamases

The invention relates to an indane compound according to Formula (I), or a pharmaceutically acceptable salt thereof, wherein R, R, R, R, R, R, L, n and p are as defined herein. The compounds are useful for treating antibacterial infection either as stand-alone antibiotics, or in combination with further antibiotics.

Indane derivatives for use in the treatment of bacterial infection

Diazabicyclooctanones as inhibitors of serine beta-lactamases

The invention relates to a compound which is a thiazole derivative of Formula (I), or a pharmaceutically acceptable salt thereof, wherein R, R, R, R, R, R, R, Formula (A), Z, L, X, m, n and p are as defined herein. The compounds are useful in the treatment and prevention of bacterial infection. The invention also relates to combinations of the compound of Formula (I) with further active agents. 

Chemical compounds

The invention relates to a compound which is an indane derivative according to Formula (I), or a pharmaceutically acceptable salt thereof, [FORMULA (I)] wherein R, R, R, n, R, p, q, L, X and m are as defined herein. The compounds are useful in the treatment of antibacterial infection either as stand alone antibiotics, or in combination with further antibiotics. The compounds can also be used in vitro, for example in cleaning compositions. 

Chemical compounds as antibiotics

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Labege, France

Simon Leiris