Institut National De La Sante Et De La Recherche Medicale

Université Paris Diderot-Paris 7

Koninklijke Philips Corporation N.v.

Centre National De La Recherche Scientifique

Assistance Publique-Hopitaux De Paris

Assistance Publique - Hopitaux De Paris (Aphp)

Université De Versailles—saint-Quentin-En-Yvelines

Université Versailles Saint-Quentin-En-Yvelines

Universite Paris Cité

Simon Lambert

Benjamin Leporq

Ralph Sinkus

Bernard Van Beers

Bernar Van Beers

Sabrina Nicole Dolorès Doblas

Philippe Francois Thierry Garteiser

Valérie Paradis

Leon Christiaan Terbeek

Leon Christiaan Ter Beek

In the field of obesity related disease, identification of patients with nonalcoholic steatohepatitis (NASH) would be useful to counsel them more intensively on diet and lifestyle changes and propose new pharmacological treatments. As a consequence, the inventors worked on a method for post-processing images of a region of interest of the liver for reconstructing a map of the internal magnetic susceptibility by using a Bayesian regularization approach to inverse the internal magnetic field. Such method can be implemented on computer and provides better results than other known methods for obesity related disease. This method may be applied for predicting that a subject is at risk of suffering from such disease, diagnosing a disease, identifying a therapeutic or a biomarker and screening compounds useful as a medicine.

Method for post-processing liver MRI images to obtain a reconstructed map of the internal magnetic susceptibility

The invention provides for a medical apparatus () for treating cells of a subject comprising at least one transducer () with a vibrating surface (). The transducer further comprises an applicator () for attaching the vibrating surface to an outer surface of the subject (). The transducer is operable to vibrate at a frequency between 10 Hz and 1000 Hz. The medical apparatus further comprises a controller () for controlling the vibration of the transducer. The controller is operable for causing the transducer to vibrate for greater than a predetermined period of time for treating the cells. The predetermined period of time is greater than one hour.

Medical apparatus for treating cells with vibrations

It is proposed a method for post-processing images of an region of interest in a subject, the images being acquired with a magnetic resonance imaging technique, the method for post-processing comprising at least the step of: &#x2014;unwrapping the phase of each image, &#x2014;extracting a complex signal over echo time for at least one pixel of the unwrapped images, and &#x2014;calculating fat characterization parameters by using a fitting technique applied on a model, the model being a function which associates to a plurality of parameters each extracted complex signal, the plurality of parameters comprising at least two fat characterization parameters, the magnitude error and the phase error generated by the use of the bipolar readout gradients, the fitting technique being a non-linear least-square fitting technique using pseudo-random initial conditions.

Method for fat characterization using MRI images acquired using a multiple gradient-echo sequence with bipolar gradients

A medical apparatus () determines the concentration distribution of sonically dispersive elements () within a subject (), wherein the medical apparatus comprises: a memory () for storing machine executable instructions () and a processor () for executing the machine executable instructions. Execution of the instructions cause the processor to: receive () shear wave data () descriptive of the propagation of shear waves () within the subject for at least two frequencies; determine () a mechanical property () of the subject using the shear wave data at each of the at least two frequencies; determine () a power law relationship () between the at least two frequencies and the mechanical property; and determine () the concentration distribution of the sonically dispersive elements within the subject using the power law relationship and calibration data ().

Determination of the concentration distribution of sonically dispersive elements

A method for post-processing images of a region of interest in a subject, the images being acquired with a magnetic resonance imaging technique, the method for post-processing comprising at least the step of:

Method for post-processing magnetic resonance imaging images in a clinical context

Growing community of inventors

Villeurbanne, France

Simon Lambert