Ge Healthcare UK Limited

Vanderbilt University

Simon L Stubbs

Nicholas Thomas

Ellen Fanning

Jinming Gu

Suzanne Hancock

Cheryl Louise Potts

Kathryn Louise Lamerton

Michael Kenneth Kenrick

Rahman Aziz Ismail

Michael John Francis

Adrian Cushing

Suzanne The Maynard Centre Hancock

Ellen Dep Of B&S Vanderbilt Uni Fanning

The present invention to relates to methods and kits which can be used to amplify nucleic acids with the advantage of decreasing user time and possible contamination. The PCR reagents are bound to a solid matrix for easy processing and amplification of DNA samples.

Solid matrix for one step nucleic acid amplification

The present invention relates to a cytochrome c-reporter fusion protein construct comprising a modified cytochrome c protein which targets the mitochondria and has a reduced ability to induce apoptosis in a living cell. The invention also relates to nucleic acid constructs encoding such protein fusions and cells stably transfected with such constructs. The stably transfected cells of the invention can be used in assays to detect apoptosis.

Cytochrome c protein and assay

The present invention relates to polypeptide and nucleic acids constructs which are useful for determining the cell cycle status of a mammalian cell. Host cells transfected with these nucleic acid constructs can be used to determine the effects that test agents have upon the mammalian cell cycle.

Cell cycle phase markers

The present invention relates to non-destructive and dynamic means for determining the cell cycle position of living cells. The invention provides stable cell lines which can be used to determine the cell cycle position, together with methods for measuring the effect of a test agent on the cell cycle position.

Cell cycle reporting cell line

Growing community of inventors

Cardiff, United Kingdom

Simon L Stubbs