Natrogen Therapeutics International, Inc.

Natrogen Therapeutics, Inc.

Simon K Mencher

Longgui Wang

Xiao Mei Liu

James P McCarron, Jr

Lian Mo

Ruihuan Chen

Xiaomei Liu

Allen Tsao

James P Mccarron

The invention relates to compositions and methods for treating lupus. The methods typically comprise the step of administrating one or more compounds selected from isoindigo, indigo, indirubin, or derivatives thereof, such as, Meisoindigo and NATURA in an amount sufficient to treat the lupus; preferably by modulating cytokine expression. Preferably the compound is in an amount less than sufficient to substantially inhibit cyclin dependent kinases.

Methods and compositions for treating lupus

The present invention is directed to a method treating prostate cancer. The method comprises administering to a patient in need thereof at least one compound selected from N-methyl-&#x394;3,3'-dihydroindole-2,2&#x2032; diketone; N-1-(&#x3b2;-D-O-triacetyl-xylopranosyl)-&#x394;3,3&#x2032;-dihydroindole-2,2&#x2032; diketone; and N-1-(&#x3b2;-D-O-triacetyl-xylopranosyl)-N&#x2032;-methyl-&#x394;3,3&#x2032;-dihydroindole-2,2&#x2032; diketone. Preferably the compound is in an amount sufficient to inhibit growth, invasion, and/or metastasis of prostate cancer cells.

Method of treating androgen independent prostate cancer

The invention relates to pharmaceutical compositions and methods of treating inflammatory-related diseases associated with pro-inflammatory cytokine expression and/or reduced expression of anti-inflammatory cytokines. The method typically comprises administration of one or more compounds selected from isoindigo, indigo, indirubin, or derivatives thereof, such as, Meisoindigo and NATURA. Preferably the pharmaceutical composition comprises one or more compounds selected from isoindigo, indigo, indirubin, or derivatives thereof, an anti-inflammatory agent, and a pharmaceutically acceptable carrier.

Methods of treating an inflammatory-related disease

The invention relates to pharmaceutical compositions and methods of treating inflammatory-related diseases associated with pro-inflammatory cytokine expression and/or reduced expression of anti-inflammatory cytokines. The method typically comprises administration of one or more compounds selected from isoindigo, indigo, indirubin, or derivatives thereof, such as, Meisoindigo and NATURA in an amount less than sufficient to inhibit CDKs.

The present invention is directed to a method for treating inflammatory arthritis in a mammal. The method typically comprises administering to an animal a therapeutically effective amount of at least one compound selected from indigo, isoindigo, indirubin or derivatives thereof, such as NATURA-&#x3b1; or NATURA. The present invention is further directed to pharmaceutical compositions that include a therapeutically effective amount of at least one compound of the invention, an anti-inflammatory arthritis agent and a pharmaceutically acceptable carrier.

Growing community of inventors

New York, NY, United States of America

Simon K Mencher